Axonal regeneration in the mammalian CNS |
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| Affiliation: | 1. Hotchkiss Brain Institute, University of Calgary, Calgary, AB T2N 4N1, Canada;2. Department of Comparative Biology and Experimental Medicine, Faculty of Veterinary Medicine, University of Calgary, Calgary, AB T2N 4N1, Canada;3. Alberta Children’s Hospital Research Institute, University of Calgary, Calgary, AB T2N 4N1, Canada;1. Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94143, USA;2. Department of Neurology, University of California, San Francisco, San Francisco, CA 94158, USA;1. Department of Molecular Biology, The Hamon Center for Regenerative Science and Medicine and Sen. Paul D. Wellstone Muscular Dystrophy Cooperative Research Center, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA;2. Quantitative Biomedical Research Center, Department of Population & Data Sciences and Department of Pediatrics, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA;1. Department of Genetics and Program in Cellular Neuroscience, Neurodegeneration, and Repair, Yale University, New Haven, CT 06520, United States;2. Section of Neurobiology and Department of Cellular and Molecular Medicine, Howard Hughes Medical Institute, University of California, San Diego, CA 92093, United States |
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| Abstract: | Axons in the adult central nervous system (CNS) of higher vertebrates are in general not capable of regeneration after injury. This is in contrast to the situation in lower vertebrates (fish and in part amphibia) and the mammalian peripheral nervous system (PNS), where severed axons can regenerate, correct synaptic connections can be formed again, and function can be restored. This enigma has been the subject of extensive studies in the last decades and a large amount of data has been accumulated. This article reviews recent developments in experimental approaches to axonal regrowth in the mammalian CNS focusing mostly on in-vivo systems. |
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