Regioselective Pd-catalyzed α-alkylation of furans using alkyl iodides |
| |
Authors: | Jiaqi Yuan Xiaofei Zhang Chunhao Yang |
| |
Institution: | State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203 China ; School of Pharmacy, University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing 100049 China, |
| |
Abstract: | Herein, direct alkylation of the C–H bond at the α-position of furans catalyzed by palladium catalyst is reported. This protocol targets α-alkylfurans, achieving moderate to good yields under very practical reaction conditions. With a broad scope of substrates and good functional group tolerance, this method will has promising utility in medicinal chemistry.A practical and regioselective strategy to synthesize α-alkylfurans via Pd-catalyzed direct C–H alkylation using alkyl iodides was developed. |
| |
Keywords: | |
|
|