三氯乙烯药疹样皮炎患者血清甲状腺素水平的观察

目的：观察三氯乙烯药疹样皮炎患者血清甲状腺激素水平的变化。方法选择2009年1月至2013年12月住院治疗的三氯乙烯药疹样皮炎患者65例作为研究对象，选取同期正常体检人员65名作为对照组。化学发光法检测所有研究对象血清中 TSH、FT3、FT43项甲状腺功能指标；统计所有三氯乙烯药疹样皮炎患者的激素使用总剂量。结果三氯乙烯药疹样皮炎患者血清甲状腺素水平均明显低于健康对照组：FT3（2.86±1.56 vs.4.70±0.92 pmol／L）、FT4（8.86±5.15 vs.16.07±3.02 pmol／L）、TSH （1.23±1.28 vs.2.71±1.35 mIu／l），P 均＜0.01。三氯乙烯药疹样皮炎患者中高剂量激素组甲状腺激素水平明显低于低剂量激素组：FT3（1.39±0.81 vs.1.39±0.81 pmol／L）、FT4（4.12±2.83 vs.11.81±3.92 pmol／L）、TSH （0.41±0.15 vs.1.75±1.40 mIu／l），P 均＜0.01。结论三氯乙烯药疹样皮炎患者甲状腺素水平明显降低，三氯乙烯药疹样皮炎患者测定甲状腺激素水平有助于判断疾病严重程度和预后。

Determination on the level of serum thyroid hormone in patients with trichloroethylene-induced medica-mentosa-like dermatitis

Objective To observe the changes in the serum level of thyroid hormone in patients with trichloroethylene （TCE）-induced medicamentosa-like dermatitis.Methods Sixty five patients diagnosed with TCE-induced medicamentosa-like dermatitis were enrolled in this study between January 2009 and Decem-ber 201 3.Sixty five healthy subjects were used as normal controls.Serum levels of thyroid-stimulating hormone （TSH）,free triiodothyronine （FT3 ）and free thyroxine （FT4 ）were measured using chemiluminescence meth-od.Total dose of steroid hormones administered for all patients with TCE-induced medicamentosa-like dermati-tis was statistically calculated.Results The serum levels of thyroid hormones in TCE-induced medicamentosa-like dermatitis patients were significantly lower than those in healthy controls：FT3 （2.86 ±1 .56 vs.4.70 ± 0.92 pmol/L）,FT4 （8.86 ±5.1 5 vs.1 6.07 ±3.02 pmol/L）and TSH （1 .23 ±1 .28 vs.2.71 ±1 .35 mIu/L）（all P 〈0.01 ）.The serum levels of thyroid hormones in the high-dose group were significantly lower com-pared with those in the low-dose group：FT3 （1 .39 ±0.81 vs.1 .39 ±0.81 pmol/L）,FT4 （4.1 2 ±2.83 vs.1 1 .81 ±3.92 pmol/L）and TSH （0.41 ±0.1 5 vs.1 .75 ±1 .40 mIu/l）（all P 〈0.01 ）.Conclusions The serum levels of thyroid hormones in TCE-induced medicamentosa-like dermatitis patients are significantly lower than those in healthy counterparts.Detection of thyroid hormone levels is beneficial to the evaluation of the se-verity and prognosis for this disease.