血浆脂蛋白相关性磷脂酶 A2水平与脉搏波传导速度相关性临床研究

目的：探讨血浆脂蛋白相关性磷脂酶 A2水平（Lp-PLA2）与脉搏波传导速度（PWV）的相关性。方法采用横断面研究方法，收集168例非心脑血管动脉粥样硬化性疾病患者，检查所有入选者血浆 Lp-PLA2水平以及 PWV，同时收集其他相关资料。依据血浆 Lp-PLA2水平分为正常组和升高组，比较两组相关资料以及与 PWV 相关的独立危险因素。结果与正常组相比，Lp-PLA2水平升高组 PWV 及血浆 Lp-PLA2水平明显升高，差别具有统计学意义（P ＜0.01）；其余各指标如年龄、吸烟情况、糖尿病等两组间无明显差别。多重线性回归分析提示，年龄、高血压以及血浆Lp-PLA2水平均与 PWV 独立相关，其他传统危险因素如吸烟、血糖以及胆固醇等与 PWV 无独立相关性。结论在动脉粥样硬化早期，血浆 Lp-PLA2水平升高与脉搏波传导速度具有独立相关性。

Clinical analysis of the correlation between lipoprotein-associated phospholipase A2 and pulse wave ve-locity

Objective To investigate the correlation between lipoprotein-associated phospholipase A2 （Lp-PLA2 ）and pulse wave velocity （PWV）.Methods A cross-sectional clinical trial including 1 68 partici-pants without overt cardiovascular diseases was conducted.The serum levels of Lp-PLA2 and PWV and alterna-tive laboratory parameters were measured.All participants were divided into normal and elevated groups accord-ing to the serum levels of Lp-PLA2.Relevant parameters and PWV-associated risk factors were statistically compared between two groups.Results Compared to the normal Lp-PLA2 group,the number of hypertensive patients and serum level of Lp-PLA2 were significantly higher in the elevated group （P〈0.01 ）,whereas no statistical significance was observed in other risk factors such as age,smoking and diabetes between two groups.Multiple lineal regression analysis revealed that age,PWV and Lp-PLA2 were independently associated with PWV,and other traditional risk factors such as smoking,blood glucose and cholesterol were not independ-ently correlated with PWV.Conclusion In the early stage of atherosclerosis,increased serum level of Lp-PLA2 was independently associated with PWV.