| p53和c—myc异常表达与膀胱癌多药耐药性 |
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| 引用本文： | 周兴,梅骅中.p53和c—myc异常表达与膀胱癌多药耐药性[J].肿瘤研究与临床,1998,10(3):145-147. |
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| 作者姓名： | 周兴 梅骅中 |
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| 作者单位： | 第一军医大学珠江医院，中山医科大学附属第一医院 |
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| 摘 要： | 为探讨ｐ５３和ｃ－ｍｙｃ基因异常表达与膀胱癌多药耐药性（ＭＤＲ）的关系，应用ＡＢＣ免疫组织化学方法检测６７例膀胱癌癌细胞中ｐ５３和ｃ－ｍｙｃ的表达产物及多药耐药基因（ｍｄｒ－１）产物Ｐ－ｇｐ。结果显示ｐ５３突变蛋白蓄积的膀胱癌中Ｐ－ｇｐ阳性表达率９２．３％；ｐ５３阴性者Ｐ－ｇｐ阳性率为３６．６％。Ｐ－ｇｐ表达与ｐ５３突变蛋白蓄积呈显著正相关（ｒ＝０．６４，Ｐ＜０．０５）；而ｃ－ｍｙｃ和ｍｄｒ－１的表达无明显相关。提示：ｐ５３异常表达可增加ｍｄｒ－１基因的表达，使膀胱癌细胞获得ＭＤＲ表型
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| 关 键 词： | 膀胱肿瘤 p53 c-myc P-gp 多药耐药性 |
CORRELATION BETWEEN THE ABNORMAL EXPRESSION OF p53 AND c myc WITH MULTIDRUG RESISTANCE IN BLADDER CANCER |
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| Zhou Xing,Mei Hua,Liu Chunxiao,et al The Second Affiliated Hospital of the First Military Medical University.CORRELATION BETWEEN THE ABNORMAL EXPRESSION OF p53 AND c myc WITH MULTIDRUG RESISTANCE IN BLADDER CANCER[J].Cancer Research and Clinic,1998,10(3):145-147. |
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| Authors: | Zhou Xing Mei Hua Liu Chunxiao The Second Affiliated Hospital of the First Military Medical University |
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| Abstract: | In order to study the correlation between abnormal expression of p53 and c myc with multidrug resistance (MDR) in bladder cancer,and by using ABC immunohistochemical methods, the expression products of p53 and c myc and P gp/mdr 1 in 67 cases of bladder cancer was tested. The P gp positive rate of p53 protein accumulation in bladder cancer was 92.3%, while P gp positive rate of p53 negitive was 36.6%. A significant correlation was found between p53 protein accumulation and mdr 1 gene expression ( r =0.64, P <0.05),while there was no correlation between c myc and mdr 1. p53 protein accumulation might increase the expression of mdr 1 gene, and the bladder cancer cell can get MDR phenotype. |
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| Keywords: | Bladder cancer p53 protein c myc P gp Multidrug resistance |
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