p53基因蛋白在肺癌组织中的表达及其意义

为了探索ｐ５３蛋白与肺癌的组织学类型、淋巴结转移等因素的关系。用免疫组织化学方法检测了５４例肺癌ｐ５３蛋白的表达。结果表明，阳性表达率为肺鳞癌２７．３％（６／２２），腺癌３６．８％（８／２０），腺鳞癌１００％（１／１），小细胞癌７５％（９／１２）。随着分化程度的不同表达率亦不同，高中低分化肺癌分别为３５．７％、４２．９％、４５．５％。淋巴结有无转移的患者ｐ５３蛋白表达率分别为４８．４％和３４．８％，各组之间的差异较显著。提示：ｐ５３蛋白表达可以反应肺癌细胞的活性，为研究肺癌的生物学行为提供了一个良好的标志物。

THE EXPRESSION AND SIGNFICANCE OF p53 PROTEIN IN LUNG CARCINOMAS

Immunohistochemical analysis of p53 protein expression was carried out on 54 lung carcinomas. The results showed that the rate of positive expressiion were 27.3% in squamous cell carcinoma and 36.8% in adenocarcionma. The expression rates correlated with the degree of differentiation, and were 35.7%,42.9% and 45.5% respectively in highly,moderately and poorly differentiated lung carcinomas. The expression rates of p53 protein were 48.4% in those with lymph node metastasis and 34.8% in those without lymph node metastasis. The difference were obvious among groups. The result suggested that p53 protein expression may be related with activity of lung carcinoma cells and may be a good marker in lung carcinomas.