利尿剂与ACEI联合应用治疗轻中度原发性高血压的疗效评价

目的评估利尿剂（氢氯噻嗪）与ACEI（血管紧张素转化酶抑制剂）联合应用治疗轻中度原发性高血压的疗效。方法 180例原发性高血压患者随机分为A、B2组,A组接受依那普利10mg＋氢氯噻嗪10mg,1次/d,B组接受缬沙坦80mg＋氢氯噻嗪10mg,1次/d,治疗8周复查疗效。结果动态血压监测结果显示,2组治疗后24h平均收缩压、舒张压均显著降低（P〈0.001）。但A组血压降低效果较B组明显。结论依那普利＋氢氯噻嗪的降压效果优于缬沙坦＋氢氯噻嗪。

To Assess the Efficacy of Combination with Diuretic and ACEI to Treatment Mild and Moderate Essential Hypertension

Objective To assess the efficacy Of enalapril＋hydrochlorothiazide and valsartan＋hydrochlorothiazide in patients with mild and moderate primary hypertension.Methods 180 patients with primary hypertension were randomly divided into A,B groups,A group received enalapril 10mg＋Hydrochlorothiazide 10mg,1 times/day,B group received valsartan 80mg＋Hydrochlorothiazide 10mg,1 times/day,Evaluation of efficacy of treatment for 8 weeks.Results Dynamic monitoring of blood showed that 24h after treatment,mean systolic and diastolic blood pressure were significantly decreased（P0.001）.However,group A than group B blood pressure was significantly lower degree.Conclusion The antihypertensive efficacy of enalapril ＋ hydrochlorothiazide is better than that of valsartan＋hydrochlorothiazide.