血浆纤维蛋白原与胆道梗阻关系的初步研究

目的对血浆纤维蛋白原（fibrinogen，FIB）与胆道梗阻的关系进行初步探讨。方法113例胆道疾病患者分成四组：A胆道结石组、B胆道结石＋胆道感染组、C胆道结石＋胆道感染＋胆道梗阻组、D壶腹癌＋胆道梗阻组。比较四组间FIB的差异，分析C组中FIB升高者与正常者间的生化及凝血功能指标的差异。结果A、B组间与C、D组间FIB差异无统计学意义（P〈0．05）。C、D组与A、B组间FIB差异有统计学意义（P〈0．05）。C组中FIB≤4g／L者与〉ag／L者组间胆红素值差异有统计学意义（P〈0．05）。结论胆道梗阻是导致血浆FIB升高的原因，阻塞性黄疸的患者若Fib〈ag／L可能表示肝功能损害严重。

Relationship between the Plasma Fibrinogen and Biliary Tract Obstruction

Objective To investigate the relationship between plasma fibrinogen and biliary tract obstruction. Methods 113 cases of patients with bile duct disease were divided into four groups： Group A, biliary tract stones; Group B, biliary tract stones with biliary tract infection; Group C, biliary tract stones with biliary tract infection and biliary tract obstruction; Group D, ampullary carcinomas with biliary tract obstruction. The differences of fibrinogen levels among four groups were analyzed. According to the levels of fibrinogen, Group C was divided into normal group and abnormal group. Indexes of biochemical function and blood coagulation were compared. Results There were signicant.differences between groups C, D and groups A, B （P 〈 0.05 ）. In group C, statistical differences in bilirubin were observed between the high fibrinogen group （ 〉 4g/L ） and low fibrinogen groups （≤ 4g/L ）. Conclusion Biliary tract obstruction can lead to increasing of plasma fibrinogens. The fibrinogen level lower than 4g/L in patients with obstructive jaundice is indicating serious damage of liver.