2型糖尿病合并非酒精性脂肪肝的临床特征及危险因素分析

目的探讨2型糖尿病（T2DM）合并非酒精性脂肪肝（NAFLD）的临床特点及危险因素。方法记录两组患者的年龄、性别、身高（H）、体重（W）、血压（BP）、血肌酐（Scr）、血尿酸（UA）等指标，计算体重指数（BMI）=体重（kg），身高（m^2）及腰臀比（WHR）。比较T2DM合并NAFLD（A组，n=69）与T2DM不合并NAFLD（B组，n=75）的患者之间的临床特征。结果两组患者的SBP、DBP、TG无明显差异（P〉0．05），A组患者年龄、BMI、FPG、TC、HDL—C、LDL—C、WHR、FINS均高于B组（P〈0．05）。BMI、LDL—C、TG是糖尿病脂肪肝形成的主要危险因素（P〈0．05）。结论非酒精性脂肪肝是2型糖尿病的主要并发症，是独立于体重指数及脂肪分布类型以外的相关因素。

Clinical Characteristics and Risk Factors of Type 2 Diabetes Mellitus Combined with NAFLD

Objective To investigate the clinical characteristics and related factors of type 2 diabetes mellitus combined with nonalcoholic fatty liver disease （ NAFLD ）. Methods Patients were divided into two groups on the basis of wheather they had NAFLD complications. Age, sex, height （ H ）, weight （ W ）, blood pressure （ BP ）, serum creatinine （ Scr ） and blood uric acid （ UA ） were recorded, and BMI and WHR were calculated in the two groups. Clinical characteristics were compared between T2DM with NAFLD and without NAFLD. Results No significant differences （P 〉 0.05 ） were observed between the two groups on SBP, DBP and TG indexes. But several indexes including age, BMI, FPG, TC, HDL-C, LDL-C, WHR, FINS were remarkably higher than B group. BMI, LDL-C, TG were the main risk factors of fatty liver occurrence in patients with diabetes. Conclusion NAFLD is a major complication and correlative factor independent of body mass index and fat distribution types for patients with type 2 diabetes.