| 白细胞相关免疫球蛋白样受体-1在宫颈癌和子宫内膜癌患者外周血T细胞的表达及意义 |
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| 引用本文： | 付爱丽,曹奇志,梅延辉,曹晏宁,薛江楠,张晓姝.白细胞相关免疫球蛋白样受体-1在宫颈癌和子宫内膜癌患者外周血T细胞的表达及意义[J].国际免疫学杂志,2012,35(6):466-469. |
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| 作者姓名： | 付爱丽 曹奇志 梅延辉 曹晏宁 薛江楠 张晓姝 |
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| 作者单位： | 1. 滨州医学院免疫学教研室,烟台,264003
2. 滨州医学院附属医院泌尿外科,256603 |
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| 基金项目： | 国家自然科学基金（81001300,81273200）;山东省自然科学基金（ZR2010HM072）;山东省高校科技计划资助项目（J08LG04） |
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| 摘 要： | 目的 研究白细胞相关免疫球蛋白样受体(LAIR-1)在宫颈癌和子宫内膜癌患者外周血T细胞的表达情况,并与子宫肌瘤、子宫癌前病变患者相比较,探讨LAIR-1表达与肿瘤免疫的相关性.方法 密度梯度离心法分离外周血单个核细胞,流式细胞术检测LAIR-1在196例肿瘤患者外周血T细胞的表达水平.结果 流式细胞术检测结果显示,宫颈癌和子宫内膜癌患者外周血CD3+CD4+T细胞LAIR-1阳性率均高于子宫肌瘤(P＜0.001;P＜0.05)和癌前病变患者(P ＜0.001;P ＜0.01).平均荧光强度分析结果显示,宫颈癌患者外周血CD3+CD4+T细胞LAIR-1表达水平显著高于癌前病变患者(P＜0.01),CD3+CD8+T细胞LAIR-1表达水平显著高于子宫肌瘤患者(P＜0.05)和癌前病变患者(P＜0.001).子宫内膜癌患者外周血CD3+CD4+T细胞LAIR-1表达水平明显高于子宫肌瘤患者(P＜0.05)和癌前病变患者(P＜0.01),CD3+CD8+T细胞LAIR-1表达水平高于癌前病变患者(P＜0.05).结论 LAIR-1在宫颈癌和子宫内膜癌患者外周血T细胞表达上调,提示LAIR-1可能与肿瘤免疫逃逸存在相关性.
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| 关 键 词： | 抑制性受体 LAIR-1 宫颈癌 子宫内膜癌 免疫逃逸 |
Expression and significance of leukocyte-associated immunoglobulin-like receptor-1 on T ceils from peripheral blood of patients with cervical cancer and endometrial carcinoma |
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| FU Ai-li
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CAO Qi-zhi
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MEI Yan-hui
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CAO Yan-ning
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XUE Jiang-nan
,
ZHANG Xiao-shu.Expression and significance of leukocyte-associated immunoglobulin-like receptor-1 on T ceils from peripheral blood of patients with cervical cancer and endometrial carcinoma[J].International Journal of Immunology,2012,35(6):466-469. |
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| Authors: | FU Ai-li CAO Qi-zhi MEI Yan-hui CAO Yan-ning XUE Jiang-nan ZHANG Xiao-shu |
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| Institution: | . Department of Immunological, Binzhou Med- ical University, Yantai 264003, China |
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| Abstract: | Objective To investigate the expression of leukocyte-associated immunoglobulin-like receptor-1 （LAIR） -1 in T cells from the peripheral blood of patients with cervical cancer and endometrial carcino- ma. Methods Peripheral blood mononuclear ceils （PBMCs） were isolated from the peripheral blood of 196 tumor patients. Flow cytometry was used to analyze the expression of LAIR-1 in T cells. Results The number of CD3^＋ CD4^＋ T cells expressing LAIR-1 in patients with cervical cancer and endometrial carcinoma was greater than that in patients with hysteromyoma（ P 〈 0. 001, P 〈 0.05 ）and precancerous lesion （P 〈 0. 001, P 〈 0.01 ） respectively. Mean fluorescence intensity （MFI） analysis showed that the expression of LAIR-1 in CD3^＋ CD4^＋ T cells in patients with cervical cancer was higher than that in precancerous lesion patients（ P 〈 0.01 ） , the expression of LAIR-1 in CD3^＋ CD8^＋ T ceils was higher than that in patients with hysteromyoma（ P 〈 0.05 ）and precancerous lesion（P 〈0.001 ）. The expression of LAIR-1 in CD3^＋ CD4^＋T cells in patients with endometrial carcinoma was higher than that in patients with hysteromyoma（ P 〈 0.05 ） and precancerous lesion（ P 〈 0.01 ） , the expression of LAIR-1 in CD3^＋ CD8^＋ T cells was higher than that in patients with precancerous lesion （ P 〈 0.05 ）. Conclusions The expression of LAIR-1 in T cells of patients with cervical cancer and endometri- al carcinoma was up-regulated. |
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| Keywords: | Inhibitory receptors LAIR-1 Cervical cancer Endometrial carcinoma Immune escape |
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