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| MGMT表达与替莫唑胺治疗多形性胶质母细胞瘤耐药的关系 | |
| 引用本文： | 史恩红,张东利,李鹏程. MGMT表达与替莫唑胺治疗多形性胶质母细胞瘤耐药的关系[J]. 国际免疫学杂志, 2012, 35(6): 453-456 |
| 作者姓名： | 史恩红 张东利 李鹏程 |
| 作者单位： | 1. 黑龙江省医院肿瘤科,哈尔滨,150036 2. 黑龙江省医院急诊科,哈尔滨,150036 3. 黑龙江省医院儿科,哈尔滨,150036 |
| 摘 要： | 多形性胶质母细胞瘤是中枢神经系统最常见的恶性肿瘤,而且在胶质瘤中恶性程度最高.替莫唑胺为治疗多形性胶质母细胞瘤的新型烷化剂类口服化疗药物,研究表明替莫唑胺的耐药机制与O6-甲基鸟嘌呤-DNA甲基转移酶(MGMT)的表达相关.了解多形性胶质母细胞瘤应用替莫唑胺治疗的耐药性与MGMT表达的相关性对临床治疗很有帮助. |
| 关 键 词： | 多形性胶质母细胞瘤 替莫唑胺 MGMT |
O^6-Methylguanine DNA methyltransferase protein expression and TMZ resistance in patients with glio. blastoma multiforme |
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| SHI En-hong , ZHANG Dong-li , LI Peng-cheng. O^6-Methylguanine DNA methyltransferase protein expression and TMZ resistance in patients with glio. blastoma multiforme[J]. International Journal of Immunology, 2012, 35(6): 453-456 | |
| Authors: | SHI En-hong ZHANG Dong-li LI Peng-cheng |
| Affiliation: | . Department of Oncology, Hei- Longjiang Province Hospital,Harbin 150036, China Proofreader： REN Huan, E-mail ： huanren2009@ 126. corn |
| Abstract: | Glioblastoma multiforme （GBM） is one of the most frequently occurring tumors in the central nervous system and the most malignant tumor among gliomas. Temozolomide is a newly alkylating oral drug on the treatment of glioblastoma multiforme. Some studies indicated that protein expression of 06-methylguanine-DNA-methyhransferase （MGMT） is the most important determinant of TMZ resistance. Here, the relationship of MGMT expression with TMZ resistance in glioblastoma muhiforme patients will be reviewed. |
| Keywords: | Glioblastoma muhiforme Temozolomide O^6-methylgu-anine-DNA-methyltransferase |
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