奥氮平和思瑞康治疗精神分裂症的对照研究

目的比较奥氮平和思瑞康治疗精神分裂症的疗效和安全性。方法将 98例符合CCMD 3精神分裂症患者随机分为两组 ,每组 49例 ,分别给予奥氮平和思瑞康治疗 ,疗程共 8周 ,采用阳性症状与阴性症状量表 (PANSS) ,不良反应症状量表 (TESS)评定疗效与不良反应。结果奥氮平组有效率 93 .9% ,显效率 81.6%。思瑞康组有效率 91.8% ,显效率 77.6% ,两药疗效无显著性差异 (P >0 .0 5 )。两药锥体外系反应不明显 ,较少引起内分泌的改变。奥氮平组体质量增加发生率比思瑞康组明显( 3 2 .7% :14 .3 % ,P <0 .0 5 ) ,思瑞康组嗜睡、头昏发生率均比奥氮平组明显 ( 2 4.5 % :8.2 % ,P <0 .0 5 ;2 2 .4% :6.1% ,P <0 .0 5 )。结论奥氮平和思瑞康对精神分裂症疗效相当 ,其副反应轻 ,安全性高。

Comparative study on the effect of olanzapine and seroquel of schizophrenia

ObjectiveTo compare efficacy and safety of olanzapine and seroquel in the treatment of schizophrenia.Methods 98 patients with schizophrenia by CCMD-3 were randomly allocated to two groups treated with olanzapine or seroquel for 8 weeks. The Positive and Negative Syndrome Scale(PANSS) and Treatment Emergent Side effect Scale(TESS) were used to evaluate efficacy and adverse effect respectively before and at the ends of 2,4,8 weeks of treatment. ResultsThe efficacy rates of olanzapine was 93.9%,and the significant efficacy rates was 81.6%. The efficacy rate of seroquel was 91.8%, and the significant efficacy rates was 77.6%.Both drugs showed low extrapyramidal symptoms and less endocrine change during treatment. The rate of weight gain in olanzapine group was higher than that in seroquel group(32.7%:14.3%,P<0.05). The rate of drowsiness and feel dizzy in seroquel group was higher than those in olanzapine group(24.5%:8.2%,P<0.05; 22.4%:6.1%,P<0.05). ConclnsionThe results suggest that olanzapine is as effective and safe as seroquel for the treatment of sihizophrenia and fewer side effect.