Antifungal potential of disulfiram. |
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| Authors: | Seema Khan Smita Singhal Tarun Mathur Dilip J Upadhyay Ashok Rattan |
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| Affiliation: | Department of Infectious Diseases, New Drug Discovery Research, R and D III, Sarhaul, Sector-18, Ranbaxy Research Laboratories, Gurgaon-122001, India. |
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| Abstract: | Disulfiram, an alcohol antagonistic drug has been on the market since 1949 with 80% bioavailability and an established safety profile. Recently it has been reported as a P-glycoprotein efflux pump modulator. Herein we report its antifungal potential. The MIC50 and MIC90 of disulfiram for yeast isolates is 4 and 8 microg/ml, respectively, and the MIC range is 1-16 micro g/ml for both fluconazole sensitive and resistant strains. Interestingly, disulfiram also showed fungicidal activity on Aspergillus spp. with MIC50 and MIC90 of 2 and 8 microg/ml, respectively. |
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