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Correlation analysis between serum vitamin D levels and disease activity as well as bone mineral density in children with juvenile idiopathic arthritis

??Objective??To assessed serum level of 25??OH??D3 in children with juvenile idiopathic arthritis, in order to find the association between the vitamin D and disease activity as well as bone mineral density. Methods??We evaluated 110 patients??58 females and 52 males??mean age being 9.04±3.37 years?? that fulfilled the 2011 ILAR criteria for juvenile idiopathic arthritis. Patients underwent laboratory tests of serum25??OH??D3??plasma parathyroidhormone and dual-energyx-ray absorptiometry examination. JIA patients were categorized by ACR standard of disease status in 2011??and the disease activity was measured by using JADAS-27. We analyzed the relationship between serum 25??OH??D3 level and other indexes. Results??The mean serum 25??OH??D3 level of 110 JIA patients was??49.8±15.3?? μmol/L. Vitamin D deficiency was detected in 59 patients??53.6%?? and insufficiency in 43 patients??39.1%??. Patients with active disease had significantly reduced serum 25??OH??D3 levels compared to patients with inactive disease??t??5.162??P??0.001????but there was no significant association between serum 25??OH??D3 level and JADAS-27??r??-0.72??P??0.05??. JIA patients with vitamin D deficiency showed a significantly lower bone mineral density than those with normal 25??OH??D3 level??t??3.791??P??0.05??. Patients using glucocorticoid showed significantly lower 25??OH??D3 level than those who never used glucocorticoid??t??2.823??P??0.01??. Conclusion??JIA patients have reduced serum 25??OH??D3??particularly those with active disease or/and using glucocorticoid. JIA patients with vitamin D deficiency showed a significantly lower bone mineral density.