年龄与卵巢功能——对卵巢衰老的认识

女性生育力高峰出现在20~30岁的中、晚阶段,此后生育力逐渐降低直到绝经。生育力下降发生在FSH水平上升,抑制素B下降和月经周期长度改变之前。抗苗勒管激素是较抑制素B出现更早的标志物。窦卵泡数的变化和月经周期长度可变性增强反映生殖衰老加速。生殖衰老过程,在人群存在一个普遍适用的规律;但每个个体的衰老进程是她所受多种复杂因素相互作用的结果。

Age and ovary function and ovarian aging.

The female fertility reaches the peak in the middle and late stage of 20 to 30 years old.Since then，it gradually reduces， and comes to the end at menopause.Decreased fertility ability could happen before FSH levels rise， inhibin B declines and menstrual cycle length changes.Antimullerian hormone（AMH）is a marker that can predict the decline of ovarian reserve earlier than inhibin B.Changes in the number of antral follicles and menstrual cycle length variability could also reflex reproductive aging acceleration.Reproductive aging is inevitable in population.However，aging process for each individual is affected by the interaction of a variety of complex factors.