阴道微生态变化与宫颈人乳头瘤病毒感染及相关病变的关系

阴道微生态的变化或失调会导致阴道炎症的发生,阴道p H值是评价阴道微生态方便、快捷的指标。阴道p H升高时,宫颈HPV感染显著增加,多型别HPV感染率也增加,并且宫颈及阴道HPV感染引起的宫颈低度鳞状上皮内病变(LSIL)发生率升高。BV是最常见的阴道感染,其明显增加了宫颈HPV的感染风险;性传播性疾病病原体引起的感染(STI)的女性宫颈HPV感染的发生率较高;有研究提示,阴道假丝酵母菌感染、阴道滴虫感染与HPV感染无明显相关性。常见的阴道感染对宫颈病变的影响无肯定结论。

Relationship between vagina microenvironment and cervical HPV infection and HPV-associated cervical lesions.

The imbalance of vagina microenvironment could cause vaginal infection.Vaginal pH is a convenient and fast way to estimate the vagina microenvironment.The increase of vaginal pH was closely associated with cervical human pappiloma virus（HPV） infection，and even with multi-type HPV infection，which increased the incidence of low grade squamous intraepithelial lesion（LSIL） of vagina and cervix.Bacterial vaginosis（BV），a most common vaginal infection，could increase the cervical HPV infection.Women with sexually transmitted infection（STI） had higher morbidity of cervical HPV infection.It was reported that vaginal infection of Candida albicans or trichomonas would not be related to cervical HPV infection.The common vaginal infections might not be directly associated with HPV-associated cervical lesions.