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Prospect on the potential role of probiotics in treatment of autism spectrum disorders

??Autism spectrum disorder??ASD??is a severe neurodevelopmental disease. At the present time, approved and recommended treatments for ASD are mainly based on rehabilitation and educational interventions. ASD is defined by core behavioural impairments, but gastrointestinal??GI?? symptoms are commonly reported. And the GI symptoms are considered to relate to the dysbiosis of gut microbiota and a disorder of the microbiota-gut-brain axis. The alterations of epithelial integrity, immune function and neurotransmitter lead to GI symptoms and autistic behaviors associated with dysbiosis of the gut microbiota. Probiotics can be useful to restore the microbiota balance in the intestine??to alleviate GI symptoms and ameliorate behavioural symptoms associated with some ASD. Although further research and rigorous clinical trial should be required to study the effect and mechanism of probiotics in the treatment of ASD??they can be considered potential effect on ASD.