Severe cholestasis related to intraconazole for the treatment of onychomycosis |
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Authors: | Talwalkar J A Soetikno R E Carr-Locke D L Berg C L |
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Affiliation: | Division of Gastroenterology, Brigham and Women's Hospital, Boston, Massachusetts, USA. |
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Abstract: | We describe a case of prolonged cholestasis temporally associated with the use of itraconazole for onychomycosis. Peak bilirubin level of 32.0 mg/dl was documented approximately 2 months after discontinuation of the patient's itraconazole therapy, with symptoms of cholestasis persisting more than 1 month after the peak in bilirubin. Physicians should be aware of the potential for severe cholestasis associated with itraconazole usage. |
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