| 多药耐药基因及P—糖蛋白在正常涎腺组织的表达 |
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| 引用本文： | 刘浩,张建国,俞光岩.多药耐药基因及P—糖蛋白在正常涎腺组织的表达[J].现代口腔医学杂志,2001,15(1):1-2,T001. |
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| 作者姓名： | 刘浩 张建国 俞光岩 |
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| 作者单位： | 北京大学口腔医学院口腔颌面外科 |
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| 基金项目： | 国家自然科学基金资助课题(39270724) |
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| 摘 要： | 目的 探讨多药耐药基因（mdrl)与P－糖蛋白（P－gp)在正常涎腺组织的表达与功能，方法 采用PCR和免疫组化法对15例正常涎腺组织进行mdrlm RNA及p-gp的检测，结果 mdrlmRNA阳性率为40％，IOD均值为0．245，P－gp阳性率为66．7％，定位于正常涎腺的分泌管，结论 P－gp可能参与了涎腺的正常生理功能，尤其是涎腺的分泌功能。
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| 关 键 词： | 涎腺组织 涎腺肿瘤 免疫组化 多药耐药基因 P－糖蛋白 聚合酶链反应 |
The expression of both
mdrl and P-gp in normal salivary gland tissue |
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| LIU Hao,ZHANG Jianguo,YU Guangyan.The expression of both
mdrl and P-gp in normal salivary gland tissue[J].Journal of Modern Stomatology,2001,15(1):1-2,T001. |
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| Authors: | LIU Hao ZHANG Jianguo YU Guangyan |
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| Institution: | LIU Hao,ZHANG Jianguo,YU Guangyan. Department of Oral-Maxillofacial Surgery,School of Stomatology,Beijing Medical University,Beijing 100081 |
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| Abstract: | Objective To study the expression and function of mdr1mRNA and P-gp in normal salivary gland tissue.Methods 15 cases of normal salivary gland tissue were investigated by PCR and immunohistochemistry with JSB-1. Results Positive rate of normal tissue was 66.7% and 40%respectively.P-gp was located in secretory duct cells of normal gland.Conclusion P-gp may be involved in physical function of normal salivary gland tissue. |
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| Keywords: | mdrl P-gp Salivary gland tissue PCR Immunohistochemistry |
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