| Abstract: | The DNA concentration was determined microspectrophotometrically in heart muscle cell nuclei of rats at different stages of experimental myocardial infarction. In the intact rat heart some nuclei (1.5–1.8%) of myocytes had a tetraploid DNA complement. Myocardial infarction activates the polyploidization of the nuclei of the muscle cells, especially these lying around the area of injury. The highest intensity of polyploidization of the muscle nuclei was found during the first week of myocardial infarction. Later during the experiment the degree of ploidy of the myocytes increased.Central Pathological Anatomical Laboratory, Institute of Human Morphology, Academy of Medical Sciences of the USSR, Moscow. (Presented by Academician of the Academy of Medical Sciences of the USSR A. P. Avtsyn.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 83, No. 3, pp. 366–368, March, 1977. |
