| Effects of Xanthoceraside on learning and memory impairment in mice induced by i.c.v.Aβ_(1-42) |
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| 摘 要： | Objective To investigate the improvement of Xanthoceraside on learning and memory impairment in mice induced by intracerebroventricular injection of Aβ1-42(i.c.v.Aβ1-42)and the possible mechanisms of its protection against AD.Methods Y-maze test,water-maze test and step-down test were used to investigate the learning and memory ability of mice;Biochemical analysis was used to detect the activity of CAT,T-AOC,ATPase and the content of MDA.Results The results showed that Xanthoceraside could significantly increase the alternation behavior in Y-maze test,shorten swimming time in water maze test and increase the latency and decrease the number of errors and the total time of shock in step-down test.Xanthoceraside markedly increased the activity of CAT,T-AOC,ATPase,at the same time,decreased the content of MDA.Conclusions Xanthoceraside can improve learning and memory impairment in mice induced by i.c.v.Aβ1-42 significantly.The mechanism may be associated with the protection against damage induced by free radicals;the inhibition of membrane lipid peroxidation and the improvement of metabolism of brain.
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| 关 键 词： | Xanthoceraside Aβ1-42 Alzheimer\'s diseases anti-oxidation |
Effects of Xanthoceraside on learning and memory impairment in mice induced by i.c.v.Aβ_(1-42) |
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| Authors: | ZOU Li-bo CHI Tian-yan ZHAO Hong-yun LI Xiao-chun WANG Li-hua YANG Bai-zhen |
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| Institution: | ZOU Li-bo1,CHI Tian-yan1,ZHAO Hong-yun1,LI Xiao-chun1,WANG Li-hua2,YANG Bai-zhen2(1.School of Life Science , Biopharmaceutics,Shenyang Pharmaceutical University,Shenyang 110016,China,2.Shenyang Institute of Applied Ecology,Chinese Academy of Sciences,China) |
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| Abstract: | Objective To investigate the improvement of Xanthoceraside on learning and memory impairment in mice induced by intracerebroventricular injection of Aβ1-42(i.c.v.Aβ1-42)and the possible mechanisms of its protection against AD.Methods Y-maze test,water-maze test and step-down test were used to investigate the learning and memory ability of mice;Biochemical analysis was used to detect the activity of CAT,T-AOC,ATPase and the content of MDA.Results The results showed that Xanthoceraside could significantly increase the alternation behavior in Y-maze test,shorten swimming time in water maze test and increase the latency and decrease the number of errors and the total time of shock in step-down test.Xanthoceraside markedly increased the activity of CAT,T-AOC,ATPase,at the same time,decreased the content of MDA.Conclusions Xanthoceraside can improve learning and memory impairment in mice induced by i.c.v.Aβ1-42 significantly.The mechanism may be associated with the protection against damage induced by free radicals;the inhibition of membrane lipid peroxidation and the improvement of metabolism of brain. |
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| Keywords: | Xanthoceraside Aβ1-42 Alzheimer's diseases anti-oxidation |
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