Expression of Estrogen Receptor Alpha and Beta in Breast Cancers of Pre- and Post-menopausal Women |
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Authors: | Blanca Murillo-Ortiz Elva Pérez-Luque J. M. Malacara Leonel Daza-Benítez Martha Hernández-González Luis Benítez-Bribiesca |
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Affiliation: | (1) Instituto Mexicano del Seguro Social, Unidad Médica de Alta Especialidad No. 1 Bajío. Unidad de Investigación en Epidemiología Clínica, UMAE No. 1 Bajío, IMSS, B. Lopez Mateos Esq. Insurgentes S/N, Colonia: Los Paraisos, CP 37320 León, Guanajuato, Mexico;(2) Instituto de Investigaciones Médicas, Universidad de Guanajuato, León, Guanajuato, Mexico;(3) Unidad de Investigación Medica en Enfermedades Oncológicas, Hospital de Oncología, Centro Medico Nacional SXXI, México, DF, Mexico |
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Abstract: | Expression of estrogen receptors (ER) is clinically relevant in designing therapeutic strategies. The relative importance of the two types of estrogen receptors (ER-alpha and ER-beta) in human breast cancers in pre- and post-menopausal women has not been properly defined. To determine the possible association between the expression of estrogen receptor and serum estradiol levels in pre- and post-menopausal women with breast cancer. 44 patients with invasive ductal carcinoma of the breast were studied and a breast tissue biopsy was taken. ER-alpha and ER-beta were detected by immunocytochemistry. Serum levels of estradiol and estrone were measured by radioimmunoassay and FSH was measured using IRMA. We studied 21 pre- and 23 post-menopausal women with breast carcinoma. Examining the number of cases with tumors positive for ER, we found no differences in the frequency of ER-alpha between pre- and post-menopausal women, but ER-beta decreased marginally after menopause (p < 0.051). In cases with tumors positive for ER, the proportion of cells positive for ER-alpha was similar post-menopausally (53.95%) and pre-menopausally (57.21%), but for ER-beta the number of positive cells decreased significantly after menopause (p < 0.051). In pre-menopausal women there was a correlation between serum estradiol levels and ER-beta; in post-menopausal women there was a correlation between serum FSH levels and ER-alpha. These results indicate that estradiol levels in women with mammary carcinoma are related to ER-beta expression in the breast tumor tissue. |
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Keywords: | Estrogen receptor Estradiol Breast cancer |
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