| T淋巴细胞性白血病病人CCR9的功能改变 |
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| 引用本文： | 胡志芳,张秋萍,陈会敏,董兴高,谢珞琨,何玉玲. T淋巴细胞性白血病病人CCR9的功能改变[J]. 中国免疫学杂志, 2004, 20(12): 825-827 |
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| 作者姓名： | 胡志芳 张秋萍 陈会敏 董兴高 谢珞琨 何玉玲 |
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| 作者单位： | 武汉大学医学院免疫系,武汉,430071 |
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| 摘 要： | 目的：探讨趋化性细胞因子受体9(CCR9)在白血病病人中的功能改变。方法：对38例T淋巴细胞性自血病病人的血液标本进行分析。采用趋化试验和黏附试验检测胸腺表达的趋化性细胞因子TECK／CCL25(CCR9的配体)对病人CD4 T细胞的趋化功能和黏附功能的改变。结果：TECK／CCL25可以诱导几乎所有的急性T淋巴细胞性白血病(T-ALL)患者的CD4 T细胞产生强趋化移动，也可介导其发生较强的黏附作用，而对慢性T淋巴细胞性白血病(T-CLL)患者的CD4 T细胞仅显示出中度的趋化和黏附作用。结论：CCR9及其配体TECK可能与促进T-ALL CD4 T细胞的迁移和浸润有关。
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| 关 键 词： | 趋化性细胞因子受体9 TECK 急性T淋巴细胞性白血病 慢性T淋巴细胞性白血病 |
| 文章编号： | 1000-484X(2004)12-0825-03 |
The changes of functions of chemokine receptor 9 on T-cell lymphocytic leukemia patients |
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| HU Zhi Fang,ZHANG Qiu Ping,CHEN Hui Min,DONG Xing Gao,XIE Luo Kun,HE Yu Ling. The changes of functions of chemokine receptor 9 on T-cell lymphocytic leukemia patients[J]. Chinese Journal of Immunology, 2004, 20(12): 825-827 |
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| Authors: | HU Zhi Fang ZHANG Qiu Ping CHEN Hui Min DONG Xing Gao XIE Luo Kun HE Yu Ling |
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| Affiliation: | HU Zhi Fang,ZHANG Qiu Ping,CHEN Hui Min,DONG Xing Gao,XIE Luo Kun,HE Yu Ling.Department of Immunology,Medical School of Wuhan University,Wuhan 430071,China[ |
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| Abstract: | Objective:To observe the influences of functions of chemokine receptor 9(CCR9) on leukemia patients,we analyzed 38 typical T cell lymphocytic leukemia cases.Methods:The functions of T ALL and T CLL CD4 T cells towards TECK/CCL25 were determined by chemotaxis assay and adhesion assay.Results:Almost in all of the T ALL patients,TECK/CCL25(a ligand for CCR9)could induce a high chemotactic migration of T ALL CD4 cells as well as a high adhesion.Conclusion:It indicates that CCR9 and its ligands may promote survival or proliferation of T ALL cells. [ |
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| Keywords: | CCR9 TECK T ALL T CLL |
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