埃索美拉唑对幽门螺杆菌相关性十二指肠溃疡的疗效观察

目的分析埃索美拉唑治疗幽门螺杆菌（Hp）相关性十二指肠溃疡（DU）的临床疗效。方法收集48例Hp阳性DU患者，随机平分为两组，治疗纽（n=24）接受埃索荚拉唑、阿莫西林和克拉霉紊治疗，而对照纽患者（n=24）接受雷尼替丁、阿莫西林和克拉霉素治疗。治疗8周后观察临床症状情况，并通过内镜检查，观察溃疡愈合，Hp清除，并比较胃窦部炎症情况。结果经8周治疗后，发现埃索关拉唑组患者明显改善临床症状（如上腹部疼痛、上腹不适、嗳气），溃疡愈合率和HP清除率明显比对照组升高（P〈0．01），胃窦部炎症分级明显降低（P〈0．01）。结论埃索美拉唑可有效地缓解Hp相关性DU症状，加速溃疡愈合，清除HP感染，是治疗DU的一种有效方法。

Effect of omeprazole on Helicobacter pylori - related duoddemal ulcer

Objective To analyze clinical effects of esomeprazole in the treatment of Helicobacter pylori （Hp） - associated duodenal ulcer （DU）. Methods Forty - eight patients with Hp - positive DU were randomly classified into esomeprazole - （n =24） and ranitidine - （n =24） treated groups. Patients in both groups also received treatment with amoxicillin and clarithromycin. Clinical effects and inflammation changes in gastric antrum were analyzed 8 weeks after comprehensive treatment. Results Esomeprazole significantly improved clinical symptoms including epigastrlc pa/n compared with tahitidine （P 〈 0.01 ）. Esomeprazole markedly enhanced ulcer healing than ranitidine （P 〈 0.01 ）, and HP clearance rate was significantly higher in esomeprazole - treated group than in ranitidine - treated group （ P 〈 0.01 ）. Inflammation in gastric antrum was also remarkably improved （ P 〈 0.05）. Conclusion Esomeprazole is effectively to treat Hp - associated DU and enhance HP clearance and ulcer healing.