枸橼酸莫沙必利分散片治疗胃食管反流病临床研究

目的观察枸橼酸莫沙必利分散片治疗胃食管反流病的疗效和安全性。方法68例胃食管反流病患者随机分试验组：34例枸橼酸莫沙必利分散片5mg1日3次，餐前口服；对照组34例奥美拉唑20mg1日2次。餐前口服。疗程均为8周。结果两纽治疗8周后烧心、反酸症状明显改善；内镜情况均有不同程度的改善，但两组比较差异均无统计学意义（P〉0．05）。结论枸橼酸莫沙必利分散片治疗胃食管反流病疗效显著，不良反应轻微，为治疗胃食管反流病提供了一种新的选择。

Effect of Mosapride citrate in the treatment of gastroesophageal reflux disease

OBJECTIVE To evaluate the clinical efficiency and safety of mosapride citrate on gastroesophageal reflux disease. METHODS 68 patients with gastroesophageal reflux disease were randomly divided into the test group （n= 34） and the control group （n= 34） to receive mosapride citrate 5mg pc, tid and Omeprazole 20mg pc, bid, respectively for eight weeks. RESULTS After eight weeks＇ treatment, the symptoms of all patients were improved significantly, and there was no statistically significant difference in symptom scores between the two groups （P 〉0.05）. CONCLUSION Mosapride citrate is a new safety efficacious drug for treating gastroesophageal reflux disease.