郑州市HIV/AIDS患者免费抗病毒治疗的临床疗效评价

目的评价郑州市HIV／AIDS患者接受免费抗病毒治疗的效果。方法收集2004-2009年在我院接受抗病毒治疗的144例HIV／AIDS患者的临床资料并随访至2010年6月，比较分析治疗基线及治疗结束后CD4^＋T淋巴细胞水平、HIV载量变化，统计抗病毒治疗方案、机会性感染的发生、药物的不良反应等情况。结果144例中，死亡12例；存活的132例中，102例HIVRNA〈50copies／ml。132例存活患者CD4^＋T淋巴细胞计数在治疗前后比较差异有统计学意义。抗病毒治疗过程中发生药物不良反应109例次。目前达到病毒学治疗成功目标的102例中，91例采用一线抗病毒治疗方案。结论郑州市接受抗病毒治疗的绝大部分HIV／AIDS患者采用一线方案取得了良好的病毒学及免疫学效果，同时治疗过程中也出现了一定比例的不良反应。

Efficacy of national free antiretroviral treatment on HIV/AIDS patients in Zhengzhou

Objective To evaluate the efficacy of national free antiretroviral treatment on HIV/AIDS patients in Zhengzhou city. Methods Clinical data of 144 HIV/AIDS patients, who received highly active antiretroviral treatemnt （HAART） from 2004 to 2009 were collected and the patients were followed up to Jun. 2010. CD4^＋ T lymphocyte count and viral load at baseline were compared with those at the end of treatment. Antiviral treatment programs, the incidence of opportunistic infections and adverse drug reactions were calculated and evaluated. Results Of 144 patients, 12 died. Of the survived 132 patients, 102 had plasma HIV RNA levels of less than 50 copies/ml. CD4~ T lymphocyte counts of the 132 patients at baseline and after receiving HAART were significantly different. Adverse drug events occurred in 109 person-times during the course of the treatment. Of 102 patients with plasma HIV RNA levels of less than 50 copies/ml, 91 received first-line antiviral treatment programs. Conclusions Virological and immunological responses are achieved in the majority of HIV/AIDS patients in Zhengzhou city after receiving first-line antiviral treatment programs while certain proportion of adverse reactions is also found during the course of the treatment.