| MMP-2及CD147在侵袭性垂体腺瘤中的表达及其相互关系的研究 |
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| 引用本文： | 霍钢,田加坤,唐文渊,郑履平,易勇. MMP-2及CD147在侵袭性垂体腺瘤中的表达及其相互关系的研究[J]. 中国神经精神疾病杂志, 2005, 31(3): 168-171 |
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| 作者姓名： | 霍钢 田加坤 唐文渊 郑履平 易勇 |
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| 作者单位： | 重庆医科大学附属第一医院神经外科,重庆,400016 |
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| 摘 要： | 目的检测基质金属蛋白酶(MMP-2)及CD147在侵袭性和非侵袭性垂体腺瘤中的表达,以探讨其与肿瘤侵袭发生的关系及两者之间的相关性。方法用免疫组化SP法和RTPCR方法对55例垂体腺瘤患者标本MMP2及CD147的表达进行检测。结果免疫组化显示,侵袭性垂体腺瘤的MMP-2强阳性及阳性表达率明显高于非侵袭性垂体腺瘤(65.6%和93.8%,13.0%和43.5%,P<0.05),CD147强阳性及阳性表达率明显高于非侵袭性垂体腺瘤(53.1%和96.9%,21.7%和52.2%,P<0.01)。侵袭性垂体腺瘤组MMP-2及CD147mRNA的表达(1.126±0.081,0.887±0.043,P<0.01),明显高于非侵袭性垂体腺瘤组(0.425±0.083,0.179±0.051,P<0.01)。侵袭性腺瘤组中MMP2与CD147的表达成正相关(r=0.73,P<0.05),非侵袭性腺瘤组中MMP-2与CD147的表达无明显相关性(r=0.34,P>0.05)。结论MMP2及CD147的高表达与垂体腺瘤的侵袭性密切相关。MMP-2和CD147可以作为垂体腺瘤侵袭性的2项有效指标。在肿瘤侵袭过程中CD147与MMP-2的产生关系密切。
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| 关 键 词： | MMP-2 CD147 垂体腺瘤 侵袭 |
| 修稿时间： | 2005-02-27 |
The study on expression and relationship between matrix metalloproteinase-2 and CD147in invasive pituitary adenomas |
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| Huo Gang,TIAN Jia-kun,Tang Wen-yuan,ZHENG Lu-ping,Yi Yong. The study on expression and relationship between matrix metalloproteinase-2 and CD147in invasive pituitary adenomas[J]. Chinese Journal of Nervous and Mental Diseases, 2005, 31(3): 168-171 |
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| Authors: | Huo Gang TIAN Jia-kun Tang Wen-yuan ZHENG Lu-ping Yi Yong |
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| Affiliation: | HUO Gang,TIAN Jia-kun,TANG Wen-yuan,ZHENG Lu-ping,YI Yong. Department of Neurosurgery,The First Affiliated Hospital of Chongqing University of Medical Sciences,1 Yixueyuan Road,Chongqing. 400016. |
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| Abstract: | |
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| Keywords: | Matrix metalloproteinase-2 CD147 Pituitary adenomas Invasion |
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