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| 右半结肠癌p27Kip1蛋白的表达及预后意义 | |
| 引用本文： | 孙涛,刘艳茹,魏雷震,高雅苓.右半结肠癌p27Kip1蛋白的表达及预后意义[J].中国医科大学学报,2004,33(1):63-64. |
| 作者姓名： | 孙涛 刘艳茹 魏雷震 高雅苓 |
| 作者单位： | 1. 辽宁省肿瘤医院内一科 2. 苏家屯铁路医院内科 3. 中国医科大学基础医学院医学遗传学教研室 |
| 摘 要： | 目的:研究p27Kip1蛋白在右半结肠癌组织中的表达并探讨其预后应用价值.方法:通过免疫组化S-P方法对76例右半结肠癌组织标本进行p27Kip1蛋白表达的检测.结果:p27kip1染色阳性40例,占52.6% .p27kip1 蛋白水平与右半结肠癌临床分期、浸润深度、淋巴结转移、病理分级及复发均显著相关.结论:检测p27Kip1表达为判断右半结肠癌恶性程度及预后提供有价值的分子生物学指标. |
| 关 键 词： | 右半结肠癌 免疫组织化学 p27Kip1蛋白 |
| 文章编号： | 0258-4646(2004)01-0063-02 |
| 修稿时间： | 2002年12月2日 |
Clinical significance of p27Kip1 protein expression in right-sided colon cancer |
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| SUN Tao ,LIU Yan-ru ,WEI Lei-zhen ,GAO Ya-li ng.Clinical significance of p27Kip1 protein expression in right-sided colon cancer[J].Journal of China Medical University,2004,33(1):63-64. | |
| Authors: | SUN Tao LIU Yan-ru WEI Lei-zhen GAO Ya-li ng |
| Institution: | SUN Tao 1,LIU Yan-ru 2,WEI Lei-zhen 3,GAO Ya-li ng 4 |
| Abstract: | Objective: To investigate the expression o fp27 Kip1 protein in right-sided colon cancer and relationship with the bi ological behavior and prognosis. Methods: Expression of p27 Kip1 at protein level was determined by using immunohistochemistry techniqu e in 76 patients with colon cancer. Results: Forty of 76 cases(52.6%) were positively stained ( ). Significant correlations existed between e xpression of p27 Kip1 protein and the following clinicopathologicalfact ors :clinical stage, invasive depth, regional lymph node status, histologic grad e, and various modes of recurrence. No correlation was found between the express ion of p27 Kip1 protein and that of ki67 protein. Conclusion: The test of expression of p27 Kip1 protein is helpful in assessing t he malignant extent and prognosis of right-sided colon cancers. |
| Keywords: | right-sided colon cancer immunohistochemi stry p27 Kip1 protein |
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