| 抗癌活性肽对小鼠肝癌H22移植瘤生长的抑制作用 |
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| 引用本文： | 苏依拉其木格,王朝阳,托娅,苏秀兰.抗癌活性肽对小鼠肝癌H22移植瘤生长的抑制作用[J].包头医学院学报,2011,27(2):1-3. |
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| 作者姓名： | 苏依拉其木格 王朝阳 托娅 苏秀兰 |
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| 作者单位： | 内蒙古医学院附属医院,内蒙古,呼和浩特,010050;内蒙古医学院附属医院,内蒙古,呼和浩特,010050;内蒙古医学院附属医院,内蒙古,呼和浩特,010050;内蒙古医学院附属医院,内蒙古,呼和浩特,010050 |
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| 摘 要： | 目的：探讨抗癌活性肽（ACBP）对小鼠肝癌H22移植瘤生长的抑制作用及其可能机制。方法：建立小鼠H22肝癌细胞实体瘤模型,并将其随机分为三组,分别给予5-Fu（20 mg/kg）,ACBP（0.4 mL/只）和生理盐水（0.4 mL/只）,尾静脉注射,隔日给药,连续10 d;然后处死小鼠,计算重量抑瘤率（IR）和脾指数（SI）,并用流式细胞仪检测细胞周期和凋亡。结果：ACBP能显著抑制肿瘤生长,IR最高达54.20%;流式细胞术分析结果显示ACBP能阻滞肿瘤细胞于G0/G1期,并能促进瘤细胞凋亡。结论：ACBP对小鼠肝癌有显著的抑制作用,其作用机制可能是通过诱导肿瘤细胞凋亡,抑制DNA合成,从而达到抗肿瘤效应。
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| 关 键 词： | 抗癌活性肽 移植瘤 细胞凋亡 细胞周期 流式细胞术 |
Inhibition Effects of Anti-cancer Bioactive Peptide on Hepatocarcinoma H_(22) Tumor-bearing Mice |
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| SU Yilaqimuge,WANG Zhaoyang,TUO Ya,SU Xiulan.Inhibition Effects of Anti-cancer Bioactive Peptide on Hepatocarcinoma H_(22) Tumor-bearing Mice[J].Journal of Baotou Medical College,2011,27(2):1-3. |
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| Authors: | SU Yilaqimuge WANG Zhaoyang TUO Ya SU Xiulan |
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| Institution: | SU Yilaqimuge,WANG Zhaoyang,TUO Ya,SU Xiulan(The Affiliated Hospital of Inner Mongolia Medical College,Hohhot 010050,China) |
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| Abstract: | Objective:To investigate the effects of anti-cancer bioactive peptide(ACBP) on hepatocarcinoma H22 tumor-bearing mice,and to elucidate the possible mechanisms of inhibition.Methods: Animal model of hepatocarcinoma H22 tumor-bearing mice were established.And the mice were randomly divided into three groups,and were treated with 5-Fu,ACBP,physiological saline by caudal vein injection,respectively.The mice were fed 10 days and were treated every other day.Then the mice were executed,inhibitory rate(IR) and spl... |
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| Keywords: | ACBP Transplanting tumor Apoptosis Cell cycle Flow cytometry |
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