| 雷公藤T4单体和干扰素对人成纤维细胞增殖作用的影响 |
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| 引用本文： | 郑志,孙思勤,袁华音,陈逖.雷公藤T4单体和干扰素对人成纤维细胞增殖作用的影响[J].中国中医眼科杂志,2002,12(1):21-24. |
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| 作者姓名： | 郑志 孙思勤 袁华音 陈逖 |
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| 作者单位： | 1. 安徽省立医院眼科,合肥,230001
2. 安徽医科大学附属医院眼科 |
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| 摘 要： | 目的 探讨雷公藤T4单体和干扰素α -2b对人成纤维细胞增殖作用的影响。方法 人成纤维细胞常规传代培养。用比色法检测分别加入雷公藤T4单体、干扰素α -2b、 5-氟尿嘧啶及T4加 5-氟尿嘧啶后对细胞增殖的影响。结果 雷公藤T4单体、 5-氟尿嘧啶及T4加5-氟尿嘧啶对人成纤维细胞增殖有抑制作用。干扰素α -2b对人成纤维细胞增殖有促进作用。结论 雷公藤T4单体对实验性人成纤维细胞的增殖有抑制作用
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| 关 键 词： | 雷公藤 干扰素α-2b 成纤维细胞 5-氟尿嘧啶 |
| 文章编号： | 1002-4379(2002)01-0021-04 |
| 修稿时间： | 2001年8月7日 |
Effects of monomer tripterygium wilfordii T4 and interferon on cultured human fibroblasts proliferation |
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| ZHENG Zhi,SUN Siqi,YUAN Huayin,et al..Effects of monomer tripterygium wilfordii T4 and interferon on cultured human fibroblasts proliferation[J].Journal of Traditional Chinese Ophthalmology,2002,12(1):21-24. |
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| Authors: | ZHENG Zhi SUN Siqi YUAN Huayin |
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| Institution: | ZHENG Zhi,SUN Siqi,YUAN Huayin,et al. Anhui Provincial Hospital,Hefei 230001,China |
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| Abstract: | OBJECTIVE To elucidate effect of tripterygium wilfordii T4 and interferon alpha-2b on cultured human fibroblasts proliferation METHODS Cultured human fibroblasts were cultured regularly for reproduction. Monomer tripterygium wilfordii T4, interferon alpha-2b, 5-Fu, and compound of monomer tripterygium wilfordii T4 and 5-Fu were admixed respectively with culture medium. Its effect on proliferation was determined with colorimetric method. RESULTS Monomer tripterygium wilfordii T4, 5-Fu, and compound of monomer tripterygium wilfordii T4 and 5-Fu could inhibit fibroblasts proliferation, and interferon alpha-2b could stimulate its proliferation. CONCLUSIONS Monomer tripterygium wilfordii T4 could inhibit proliferation of the cultured human fibroblast. |
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| Keywords: | tripterygium wilfordii interferon alpha-2b fibroblasts 5-fluorouracil 5-Fu |
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