| IL－2和IL－6基因在急性移植物抗宿主病患者外周血单个核细胞中的表达 |
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| 引用本文： | 张萍,董学斌,王申五,陆道培. IL－2和IL－6基因在急性移植物抗宿主病患者外周血单个核细胞中的表达[J]. 北京大学学报(医学版), 1996, 0(3) |
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| 作者姓名： | 张萍 董学斌 王申五 陆道培 |
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| 作者单位： | 北京医科大学血液病研究所 |
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| 摘 要： | 目的：研究ＩＬ－２及ＩＬ－６在急性ＧＶＨＤ中的表达状态。方法：采用细胞原位杂交方法，对骨髓移植后发生急性ＧＶＨＤ患者的外周血单个核细胞检测其ＩＬ－２和ＩＬ－６的表达水平，测定积分光密度值。结果：ＩＬ－２表达在急性期与缓解后比较，ｔ＝５．９９，Ｐ＜０．００１，差异非常显著；ＩＬ－６表达在急性期与缓解后比较，ｔ＝３．５９，Ｐ＜０．０１，差异显著。结论：ＩＬ－２和ＩＬ－６在急性ＧＶＨＤ时表达升高，在缓解后降低，其表达状态有助于探讨ＧＶＨＤ的免疫病理损害机理。
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| 关 键 词： | 白细胞介素2／药理学，白细胞介素6／药理学，移植物抗宿主病／遗传学，单核细胞／遗传学 |
IL-2 AND IL-6 mRNA LEVEL IN THE PERIPHERAL BLOOD MONONUCLEAR CELLS OF PATIENTS WITH ACUTE GVHD |
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| ZHANG Ping,DONG Xuebing,WANG Shenwu,LU Daopei. IL-2 AND IL-6 mRNA LEVEL IN THE PERIPHERAL BLOOD MONONUCLEAR CELLS OF PATIENTS WITH ACUTE GVHD[J]. Journal of Peking University. Health sciences, 1996, 0(3) |
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| Authors: | ZHANG Ping DONG Xuebing WANG Shenwu LU Daopei |
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| Abstract: | Objective:To study IL-2and IL-6 mRVA expression in the peripheral blood mononuclear cells (PBMC)of patients with acute Graft-versus-host disease(GVHD) Which is a major obstacle of bone marrow transplantation(BTM).Methods:The PBMC from acte GVHD(aGVHD)following al-lo-BMT was analyzed for IL-2mRNA and IL-6mRNA 1evel with cytohybridyzation in situ technique.Integrated optical density(IOD) was measured. Results:The patient with GVHD had higher IL-2mR-NA expression in acute phase than post-remission phase(t=5. 99,P<0.001)and that the patients with GVHD had higher IL-6 mRNA expression in acute phatqe than post-remission phase(t=3.95,P<0. 01).Conclusion:This showed that analysing IL-2 and IL-6 mRNA expression increased in aGVHD patients and reduced in post-remission phase.It was helpful to understand the immuno-pathophysiologic impair mechan1ism of GVHD. |
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| Keywords: | Headings Interleukin 1/pharmacal Interleukin 6lpharmacal Graft Vs host disease/genet Monocytes/genet |
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