补肾清热毒方联合西药治疗狼疮性肾炎的疗效观察

探讨补肾清热毒方联合西药治疗狼疮性肾炎的疗效.80例治疗组患者在采用西药有效控制自身免疫反应的基础上加用补肾、清热解毒、活血化瘀的中药补肾清热毒方治疗,并同时观察西药治疗前后症状、体征及实验室相关指标.结果:总有效率治疗组为91.25%,对照组为82.56%,两组比较有显著差异(P<0.05).自身抗体、补体、血脂、24 h蛋白尿、肾功能和肾脏病理变化均有显著改善(P<0.05或P<0.01).补肾清热毒方联合西药治疗狼疮性肾炎疗效优于单纯西药治疗.

Clinical Observation of the Effects of Bushenqingredu Formula Combined withWestern-style Drugs in Treating Lupus Nephritis

The curative effects of Bushenqingredu Formula (BF) combined with western-style drugs (WD) in treating lupus nephritis were investigated. 80 Patients in the treating group were treated with BF (which exerts the effects of tonifying the kidney, clearing away heat and toxins, and promoting blood circulation and removing blood stasis) and WD (which was used for controlling autoimmune reaction); 30 patients in the control group were treated with WD alone; and the changes in symptoms, signs and laboratory criteria were observed before and after the treatment. The results showed that the total effective rate in the treating group was 91.25% while that in the control group was 82.56%, and there was a significant difference between the two effective rates (P < 0.05); and too, the values of laboratory criteria, such as autoantibody, complement, blood lipid, 24-hour urinary albumin excretion, renal function and renal pathologic changes, were all markedly improved (P< 0.05 or P < 0.01) after the BF and WD treatment. The results suggest that the effects of BF combined with WD in treating lupus nephritis were better than those of single WD.