SLE患者血清IL-10、IL-18检测及临床意义

目的:探讨SLE患者IL-10,IL-18的表达与疾病的活动性及其他临床表现的关系。方法:用ELISA检测60例LN患者和60例无肾脏受损的SLE患者血清中IL-10,IL-18表达情况。结果:SLE病情活动组血清IL-10,IL-18水平高于SLE病情稳定组,LN患者血清IL-10,IL-18水平明显高于无肾脏损害组,差异有统计学意义。SLE患者血清IL-10水平与抗核抗体滴度、抗ds-DNA抗体、C3、24h、SLEDAI评分有相关性,而和临床症状(蝶形红斑、盘状红斑、关节症状)、白细胞数、抗核小体抗体、C4、CRP、ESR之间没有相关性。SLE患者血清IL-18水平与抗核抗体滴度、抗ds-DNA抗体、24h尿蛋白定量、SLEDAI评分有相关性,而和临床症状(蝶形红斑、盘状红斑、关节症状)、白细胞数、抗核小体抗体、C3、C4、CRP、ESR之间没有相关性。结论:IL-10,IL-18可能在LN发病中起到一定作用。

The Serum IL-10, IL-18 Detection and Its Clinical Significance

Objective: To discuss IL-10, IL-18 expression in SLE patients and its relativity with the disease activity and other clinical manifestations. Methods: Serum IL-10, IL-18 level in both 60 cases of LN patients and 60 cases of SLE patients without kidney damage was detected by ELISA.Results :SLE disease activity group serum IL-10,IL-18 level higher than SLE in stable condition group,LN patients serum IL-10,IL-18 level obviously higher than no kidney damage group,the difference was statistically significant;SLE patients serum IL-10 level and resistance to nuclear antibody drops degree,resistance to ds-DNA antibody, the C3,24-hour urinary protein quantitative,there is a correlation SLEDAI score,and clinical symptoms(butterfly erythema,discoid erythema,joint symptoms),the number of white blood cell,anti nucleosome antibody,C4,CRP,ESR, there were no correlation between. Conclusions :IL-10,IL-18 may play a role in the pathogenesis in LN .