Childhood sexual abuse in relation to neurobiological challenge tests in patients with borderline personality disorder and normal controls |
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Authors: | Zweig-Frank Hallie Paris Joel Ng Ying Kin N M K Schwartz George Steiger Howard Vasavan Nair N P |
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Affiliation: | Department of Psychology, Concordia University, Montreal, Québec, Canada. |
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Abstract: | This study examined whether abnormal responses to neurobiological challenge tests in borderline personality disorder (BPD) are related to a history of childhood sexual abuse (CSA). We compared patients meeting BPD criteria (n=24), with and without histories of CSA, with normal controls (n=12) on the results of challenges with meta-chlorphenylpiperazine (m-CPP), pyridostigmine and clonidine. No differences were found between abused and non-abused patients with BPD. These results do not support the hypothesis that CSA is directly related to neurobiological abnormalities in BPD. |
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