Deficits in inhibitory avoidance after neurotoxic lesions of the ventral striatum are neurochemically and behaviorally selective |
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| Authors: | R Schwarting R J Carey |
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| Affiliation: | 1. Institute of Psychology III. University of Düsseldorf Düsseldory F.R.G.;2. Veterans Administration Medical Center and State University of New York, Upstate Medical Center, Syracuse, NY 13210 U.S.A. |
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| Abstract: | Inhibitory avoidance (step-in type) was investigated in rats subjected to neurochemical lesions of the ventral striatum. The neurotoxins 6-hydroxydopamine or 5,7-dihydroxytryptamine were used to produce selective depletions of either dopamine, norepinephrine or serotonin. Only lesions which decreased the dopamine content of the ventral striatum impaired post-shock step-in behavior. Measurement of footshock reactivity by the Flinch-Jump technique indicated that only serotonin depletion altered reactivity to footshocks. Assessment of open-field locomotor behavior showed that the dopamine-denervated rats were hypoactive (fewer rearings) compared to controls, whereas serotonin-depleted rats were hyperactive. It is concluded that the deficit in inhibitory avoidance behavior following ventral striatal dopamine loss was dissociated from its effect on locomotor activity. |
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| Keywords: | inhibitory avoidance locomotion biogenic amines ventral striatum |
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