ER、PR和Bcl-2在子宫内膜癌中的表达

目的：探讨ER、PR、Bcl-2在子宫内膜癌组织中的表达及临床意义。方法：对104例子宫内膜癌及另外30例癌旁正常组织石蜡标本用免疫组织化学的方法染色，检测ER、PR、Bcl-2的表达。结果：①子宫内膜癌中ER阳性表达率46.15%,PR阳性表达率65.38%,Bcl-2阳性表达率50.84%。癌旁正常组织中ER阳性表达率60.00%，PR阳性表达率66.66%,Bcl-2阳性表达率26.66%,两组比较Bcl-2表达差异有显著性(P<0.05),ER、PR表达差异无显著性；②PR的表达与Bcl-2表达呈正相关(r=0.216,P<0.05), ER的表达与Bcl-2表达无相关性；③在并发淋巴结转移的16例中ER阳性表达率50.00%,PR阳性表达率12.50%，Bcl-2阳性表达率25.00%，无淋巴结转移的88例ER阳性表达率45.45%，PR阳性表达率75.00%，Bcl-2阳性表达率59.09%，两组PR、Bcl-2阳性表达率比较差异有显著性(P<0.05), ER表达差异无显著性(P>0.05)；④PR的表达在高分化腺癌与低分化腺癌间差异有显著性(P<0.05)，高分化腺癌的阳性率高于低分化腺癌，ER、Bcl-2在子宫内膜高分化腺癌与低分化腺癌差异无显著性。结论：Bcl-2在子宫内膜癌中阳性表达率高，并与PR的表达呈正相关；淋巴结转移时PR、Bcl-2阳性表达率降低。PR、Bcl-2可以作为指示预后的因子。

Expressions of ER, PR, and Bcl-2 in endometrial carcinoma

Objective To determine the progesterone receptor (PR), estrogen receptor (ER), and Bcl-2 protein expressions in endometrial carcinoma and their clinical significances. Methods The expressions of PR, ER, and Bcl-2 in a total of 104 frozen tissues of endometrial carcinoma and 30 cases of paracarcinoma tissues were examined by immunohistochemistry. Results ①The expressions rates of PR, ER, and Bcal-2 protein in endometrial carcinoma were 65.38%, 46.15%, and 50.84%, respectively. They were 66.66%, 60.00%,and 26.66%, respectively, in parcarcinoma tissues. Statistically difference was found in the expressions of Bcl-2 between two groups (P<0.05), while it was not found in the expressions of ER and PR. ②Expression of PR was positively correlated with that of Bcl-2 (r=0.216,P<0.05). There was no relation between ER and Bcl-2. ③Positive expression rate of ER in 16 lymph node metastasis cases was 50.00%, those of PR and Bcl-2 were 12.50% and 25.00%,respectively. Positive expression rates of ER, PR, and Bcl-2 in 88 non lymph node metastasis cases were 45.45%, 75.00%,and 59.09%,respectively. Expressions of PR and Bcl-2 had statistically differences in the cases of lymph node metastasis or non-metastasis (P<0.05), while ER had not. ④Expression of PR was higher in highly differentiated endometrial adenocarcinoma than that in poorly differentiated one. Conclusion Positive expression rate of Bcl-2 in endometrial carcinoma is high, it is positively correlated with PR expression. PR and Bcl-2 positive expression rates in lymph node metastases cases are low. PR and Bcl-2 might be available prognostic factors.