| 正交试验法优选凌寒片的醇提取工艺 |
| |
| 引用本文： | 孟姗姗,张文斌,缪 珊,王四旺,骆文静.正交试验法优选凌寒片的醇提取工艺[J].现代医药卫生,2014(1):1-2,5. |
| |
| 作者姓名： | 孟姗姗 张文斌 缪 珊 王四旺 骆文静 |
| |
| 作者单位： | [1]第四军医大学：军事预防医学系军队劳动与环境卫生学教研室,陕西西安710032 [2]第四军医大学：药学院天然药物学教研室,陕西西安710032 |
| |
| 基金项目： | 基金项目：国家“重大新药创制”科技重大专项（2008zxJ09004-013）. |
| |
| 摘 要： | 目的通过正交试验法优选凌寒片的最佳醇提取工艺。方法以淫羊藿苷含量、干膏率为评价指标，选择乙醇浓度、乙醇用量、提取时间及提取次数为考察因素，利用L_9（3^4）正交试验确定凌寒片的醇提取工艺。结果凌寒片最佳醇提取工艺为加90％乙醇16倍量，回流提取1次，提取时间1h。结论优选出的醇提取工艺简单、可行，可作为该制剂合理开发的依据。
|
| 关 键 词： | 淫羊藿甙 醇类 工艺学 正交试验 凌寒片 |
Alcohol extract technology of optimizing cold-resistant agents on orthogonal experimentation design |
| |
| Meng Shanshan,Zhang Wenbin,Miao Shan,Wang Siwang,Luo Wenjing.Alcohol extract technology of optimizing cold-resistant agents on orthogonal experimentation design[J].Modern Medicine Health,2014(1):1-2,5. |
| |
| Authors: | Meng Shanshan Zhang Wenbin Miao Shan Wang Siwang Luo Wenjing |
| |
| Institution: | 1. Department of Occupational and Environmental Health ,Department of Military Preventive Medicine ; 2. Institute of Materia Medica, School of Pharmacy, Fourth Military Medical University,Xi＇ an, Shaanxi 710032, China) |
| |
| Abstract: | Objective To optimize the best alcohol extract technology of cold-resistant agent by orthogonal experimenta- tion design. Methods The extracting amount of icariin and the extraction rate were taken as evaluation criterion, ethanol concen- tration, alcohol amount, extraction duration and extraction times were taken as investigation factors to determine the alcohol extrac- tion technology of cold-resistant agent by L_9 （ 3^4） orthogonal experimentation. Results The optimal conditions of cold-resistant agents were as follows ：refluxing and extracting the medicinal materials once for 1 hour after adding with 16-fold 90% ethanol. Conclusion The optimal extract technology process is simple and practicable, and it can provide basis for rational exploitation of the preparations. |
| |
| Keywords: | Icariin Alcohols Technology Orthogona] test Cold-resistant agent |
| 本文献已被 CNKI 维普 等数据库收录！ |
|
