Imaging Non-Dopaminergic Function in Parkinson’s Disease |
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| Authors: | David J Brooks |
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| Institution: | (1) MRC Clinical Sciences Centre and Division of Neuroscience and Mental Health, Faculty of Medicine, Imperial College, Hammersmith Hospital, London, UK;(2) Imperial College London, Cyclotron Building, Hammersmith Hospital, Du Cane Rd, London, W12 0NN, UK |
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| Abstract: | In Parkinson’s disease (PD), there is degeneration of the cholinergic, noradrenergic, and serotonergic systems in addition
to dopaminergic projections. Function of these non-dopaminergic systems can be imaged with positron emission tomography (PET)
and single photon emission computed tomography (SPECT) and correlated with motor and nonmotor symptomatology. In addition,
neuronal loss in PD is associated with microglial activation. The role of microglia in driving the disease process remains
uncertain. This review presents and discusses current findings in these areas. |
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| Keywords: | Positron emission tomography Parkinson’ s disease Acetylcholine Serotonin Noradrenaline Microglia |
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