| 健脾理气法调节实验性FD大鼠神经递质表达的研究 |
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| 引用本文： | 刘蔚雯,李冀,王皓宇,柴剑波. 健脾理气法调节实验性FD大鼠神经递质表达的研究[J]. 光明中医, 2009, 24(2): 209-211. DOI: 10.3969/j.issn.1003-8914.2009.02.007 |
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| 作者姓名： | 刘蔚雯 李冀 王皓宇 柴剑波 |
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| 作者单位： | 福建中医学院药学系,350108;黑龙江中医药大学基础医学院,150040 |
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| 基金项目： | 黑龙江省科技厅攻关项目资助(No.GC05C31604) |
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| 摘 要： | 目的:观察健脾理气法对功能性消化不良(FD)大鼠胃肠组织神经递质表达的影响,探讨该法治疗FD的作用机制。方法:采用大鼠胃电节律失常模型,随机分为4组,应用免疫组织化学方法分别检测胃窦及十二指肠组织乙酰胆碱酯酶(AchE)、一氧化氮合酶(NOS)的表达水平。结果:FD大鼠胃窦及十二指肠组织AchE及NOS的表达较正常对照组明显减少(P<0.01)。枳术饮可显著增加胃窦及十二指肠组织AchE、NOS的阳性表达(P<0.05～0.01)。结论:健脾理气法治疗FD的作用机制可能在于调节胃窦及十二指肠神经递质Ach、NO的表达水平。
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| 关 键 词： | FD 健脾理气法 AchE NOS 中医实验医学 |
Effect of Jianpi Liqi Method on neurotransmitter of Functional Dyspepsia Rats |
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| Liu Weiwen,Li Ji,Wang Haoyu,Chai Jianbo. Effect of Jianpi Liqi Method on neurotransmitter of Functional Dyspepsia Rats[J]. Journal of Traditional Chinese Medicine, 2009, 24(2): 209-211. DOI: 10.3969/j.issn.1003-8914.2009.02.007 |
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| Authors: | Liu Weiwen Li Ji Wang Haoyu Chai Jianbo |
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| Affiliation: | Liu Weiwen Pharmacy College of Fujian college of TCM,350108,Fuzhou,Fujian,China,Li Ji,Wang Haoyu Chai Jianbo Base College of Heilongjiang University of TCM,150040,Haerbin,Heilongjiang |
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| Abstract: | Objective:To investigate the effect of Jianpi Liqi Method on neurotransmitter in rats with functional dyspepsia and its mechanism.Methods:The rat model of electrogastric dysrhythmias was used.All model were divided into 4 groups at random.The distributions of acetylcholine esterase(AchE),nitric oxide synthase(NOS)in the sinus ventriculi and dodecadactylon were observed by immunohistochemistry.Results:Compared with the normal control group,the distributions of AchE and NOS positive nerves decreased significa... |
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| Keywords: | FD Jianpi Liqi Method AchE NOS |
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