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Liposomal amphotericin-B (AmBisome) for treatment of cutaneous widespread candidosis in an infant with methylmalonic acidaemia |
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| Authors: | S. Stöckler H. Lackner G. Ginter W. Schwinger B. Plecko W. Müller |
| Affiliation: | (1) Department of Paediatrics, University of Graz, Auenbruggerplatz 30, A-8036 Graz, Austria;(2) Deparment of Dermatology, University of Graz, Auenbruggerplatz 30, A-8036 Graz, Austria;(3) Department of Paediatrics, University of Göttingen, Robert-Koch-Strasse 40, D-37075 Göttingen, Germany |
| Abstract: | In a 10-week-old infant with vitamin B12-unresponsive methylmalonic acidacmia, cutaneous candidosis (Candida albicans) progressed rapidly despite topical antifungal treatment. After 1 week of intravenous therapy with liposomal amphotericin-B (AmBisome) the dermatitis disappeared completely and blood cultures were sterile. No side-effects were observed. This is one of the first experiences in the treatment of infants with this new antifungal agent. |
| Keywords: | Methylmalonic acidaemia Cutaneous candidosis Liposomal amphotericin-B-Infant |
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