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Liposomal amphotericin-B (AmBisome) for treatment of cutaneous widespread candidosis in an infant with methylmalonic acidaemia
Authors:S. Stöckler  H. Lackner  G. Ginter  W. Schwinger  B. Plecko  W. Müller
Affiliation:(1) Department of Paediatrics, University of Graz, Auenbruggerplatz 30, A-8036 Graz, Austria;(2) Deparment of Dermatology, University of Graz, Auenbruggerplatz 30, A-8036 Graz, Austria;(3) Department of Paediatrics, University of Göttingen, Robert-Koch-Strasse 40, D-37075 Göttingen, Germany
Abstract:In a 10-week-old infant with vitamin B12-unresponsive methylmalonic acidacmia, cutaneous candidosis (Candida albicans) progressed rapidly despite topical antifungal treatment. After 1 week of intravenous therapy with liposomal amphotericin-B (AmBisome) the dermatitis disappeared completely and blood cultures were sterile. No side-effects were observed. This is one of the first experiences in the treatment of infants with this new antifungal agent.
Keywords:Methylmalonic acidaemia  Cutaneous candidosis  Liposomal amphotericin-B-Infant
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