Cytokine profile in systemic lupus erythematosus,rheumatoid arthritis,and other rheumatic diseases |
| |
Authors: | Mansour Al-Janadi Suliman Al-Balla Abdullah Al-Dalaan Syed Raziuddin |
| |
Institution: | (1) Department of Medicine, Department of Clinical Immunology, King Saud University, College of Medicine, Abha, Saudi Arabia;(2) Division of Rheumatology, Department of Medicine, King Saud University, College of Medicine, Riyadh, Saudi Arabia;(3) King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia;(4) Department of Medicine, College of Medicine, P.O. Box 641, Abha, Saudi Arabia |
| |
Abstract: | We investigated serum levels of interleukin-6 (IL-6), interferon-gamma (IFN- ), and tumor necrosis factor alpha (TNF ) from patients with systemic lupus erythematosus (SLE) and its various clinical manifestations of disease and from patients with rheumatoid arthritis (RA) and other rheumatic diseases. The serum levels of IL-6 and IFN- were highly elevated from patients with SLE associated with lymphadenopathy (LN) or nephrotic syndrome (NS). On the contrary, the serum levels of TNF were elevated from most patients with SLE associated with thrombocytopenia (TP). However, serum levels of TNF were in the normal range from patients with SLE associated with NS, LN, or central nervous system disease. Of interest, patients with SLE associated with humoral immunodeficiency disorder, hypogammaglobulinemia, had highly elevated levels of serum IL-6. The concanavalin A-stimulated mononuclear cells (MNC) of patients with SLE associated with TP secreted highly elevated levels of TNF compared to other patient groups. We suggest that abnormal production of various cytokines in SLE is an intrinsic defect of MNC and the immune system that may be the key element for a variety of clinical manifestations of this disease. |
| |
Keywords: | Systemic lupus erythematosus rheumatoid arthritis interleukin-6 interferon gamma tumor necrosis factor alpha |
本文献已被 SpringerLink 等数据库收录! |
|