类风湿关节炎合并间质性肺病的临床特点分析

目的探讨类风湿关节炎（RA）合并间质性肺病（ILD）的临床特点。方法回顾性分析2012年3月至2014年3月住院的201例RA患者的病例资料,按有无合并间质性肺病分为单纯RA组176例,RA-ILD组25例,分析比较ILD-RA的发生率、临床特征和相关危险因素。结果 RA-ILD发病率为12.44%;两组性别、发病年龄及吸烟史比较差异均有统计学意义（P〈0.05）,病程、关节肿胀数及关节压痛数比较差异无统计学意义（P〉0.05）。两组RF、CRP、抗CCP抗体及Ig G比较差异均有统计学意义（P〈0.05）,ESR、C3、C4、ANA及SSA（阳性/阴性）比较差异均无统计学意义（P〉0.05）。网格影为RA-ILD高分辨率CT（HRCT）最常见影像学表现。结论老年、男性、RF滴度高可能是RA-ILD发病的危险因素。HRCT对RA-ILD患者的早期诊断具有重要的价值。

Clinical characteristics of rheumatoid arthritis combined with interstitial lung disease

Objective To investigate the clinical characteristics of rheumatoid arthritis（ RA） combined with interstitial lung disease（ ILD）. Methods The clinical date of 201 cases of RA patients from March 2012 to March 2012 were retrospectively analyzed. All of the cases were divided into RA group（ 176 cases） and RA-ILD group（ 25 cases） according to the presence of interstitial lung disease. The incidence of RA-ILD,clinical features and risk factors were analyzed and compared. Results The incidence of RA-ILD was 12. 44%. The rate of male and female,onset age and smoking history had statistical differences between the two groups（ P〈0. 05）. The course,the number joint swelling and tenderness had no statistical differences between the two groups（ P〉0. 05）. The RF,CRP,anti CCP antibody and Ig G had statistical differences between the two groups（ P〈0. 05）. The ESR,C3,C4 and ANA and SSA had no statistical differences between the two groups（ P〉0. 05）. Grid shadow was the most common imaging of HRCT. Conclusion Elderly,male,high RF drops may be the risk factors for RA-ILD. HRCT has important value in the early diagnosis of RA-ILD.