Phthalate monoesters in association with uterine leiomyomata in Shanghai |
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| Authors: | Jing Sun Mei-Ru Zhang Li-Qian Zhang Dong Zhao Shu-Guang Li |
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| Institution: | 1. Department of Gynecology, Shanghai First Maternity and Infant Hospital of Tongji University, Shanghai, China;2. Key Laboratory of Public Health Safety of Ministry of Education, Collaborative Innovation Center of Social Risks Governance in Health, School of Public Health, Fudan University, Shanghai, China |
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| Abstract: | Phthalates are ubiquitous environmental pollutants because of the broad use of plastics. We conducted a case-control study to determine whether uterine leiomyomata were related to exposure to phthalates. Urine specimens and questionnaires were collected from 61 cases and 61 age-matched controls. Nine phthalate monoesters were determined by ultra performance liquid chromatography coupled with tandem mass spectroscopy. Cases had significantly higher levels of creatinine-adjusted mono-iso-butyl phthalate (MiBP), mono-n-butyl phthalate (MnBP), mono-2-ethylhexyl phthalate (MEHP), mono-2-ethyl-5-oxohexyl phthalate, mono-2-ethyl-5-hydroxyhexyl phthalate (MEHHP), mono(2-ethyl-5-carboxypentyl) phthalate (MECPP), total di(2-ethylhexyl) phthalate metabolites (∑DEHPmet), and total dibutyl phthalate metabolites (∑DBPmet) than controls. After adjusting for potential confounders, logistic regression analyses demonstrated that leiomyomata were positively associated with MiBP, MnBP, MEHP, MEHHP, MECPP, ∑DEHPmet, and ∑DBPmet. In summary, our data support the hypothesis that uterine leiomyomata are related to phthalate exposure. |
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| Keywords: | phthalate exposure phthalate monoesters uterine leiomyomata di-(2-ethylhexyl)-phthalate (DEHP) dibutyl phthalate |
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