熊去氧胆酸对胆道微结石性胆管炎的预防价值探讨

目的 探讨胆道微结石性胆管炎内镜治疗效果与熊去氧胆酸预防复发的作用.方法 对2006年1月至2007年7月确诊的41例胆道微结石性胆管炎患者的临床资料进行分析、随访.所有患者均行内镜治疗,根据内镜治疗后是否服用熊去氧胆酸将患者随机分为单纯内镜治疗组(20例)和内镜治疗+熊去氧胆酸组(21例).随访12个月比较两组胆管炎复发率.结果 41例患者经内镜治疗后未发生严重并发症.随访12个月,单纯内镜治疗组中,4例胆管炎复发,1例发生胰腺炎;内镜治疗+熊去氧胆酸组中无胆管炎复发,两组比较差异有统计学意义(P=0.021.结论 内镜治疗胆道微结石性胆管炎是-安全有效的方法,术后服用熊去氧胆酸可预防胆管炎复发.

Value of ursodeoxycholic acid for preventing recurrence of bile microlithiasis-associated cholangitis

Objective To explore clinical strategies of treating in bile microlithiasis-associated cholangitis and preventing the recurrence of ursodeoxycholic acid(UDCA).Methods Forty-one cases of bile microlthiasis-associated cholangitis from January 2006 to July 2007 Were analyzed and followed up.All patients underwent endoscopic therapy who were divided into UDCA group(21 cases)and non-UDCA group (20 cases)according to the use of UDCA or not besides endoscopic therapy.After using UDCA for 12 months,the complications and the incidence rate of recurrent cholangitis in each group were compared.Results Forty-one cases had no serious complications after endoscopic therapy.None had recurrent cholangitis in UDCA group,4 cases in non-UDCA group got recurrent cholangitis.One case developed pancreatitis.There was statistical significance between the two groups(P=0.021).Conclusion Endoscopic therapy is a safe and effective treatment of bile microlithiasis-associated cholangitis,and UDCA can prevent the recurrent cholangitis effectively after endoscopic therapy.