Incidence and risk factors of paediatric rotavirus diarrhoea in northern Ghana |
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Authors: | Binka Fred N,Anto Francis K,Oduro Abraham R,Awini Elizabeth A,Nazzar Alex K,Armah George E,Asmah Richard H,Hall Andrew J,Cutts Felicity,Alexander Neal,Brown David,Green Jon,Gray Jim,Iturriza-Gómara Miren Navrongo Rotavirus Research Group |
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Affiliation: | Navrongo Health Research Centre, Navrongo, Ghana. fbinka@africaonline.com.gh |
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Abstract: | We measured the type-specific incidence of paediatric rotavirus diarrhoea in an area of northern Ghana. Over 1 year, diarrhoea 1717 episodes were identified, of which 677 (39%) were positive for rotavirus. Risk factors for rotavirus infection included old age, wasting, high Vesikari score and the episode occurring in the dry season. Rotavirus-positive episodes tended to be more acute, causing vomiting and greater dehydration, and were more likely to require hospitalization. The incidence was 0.089 episodes per person-year for all diarrhoea, and 0.035 for rotavirus diarrhoea. The observed incidence decreased markedly with distance from the nearest health centre, suggesting a large unobserved burden. G2P[6], G3P[4] and G9P[8] made up more than half the genotypes detected, but the remainder were diverse. There is a large burden of rotavirus diarrhoea, but the effectiveness of future vaccines could be diluted by the high polymorphism of the virus, and the difficulty of reaching remote populations. |
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Keywords: | rotavirus diarrhoea incidence risk factors burden Ghana |
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