| 唐古特大黄多糖对大鼠实验性颅脑外伤的保护作用 |
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| 引用本文： | 王志鹏,刘莉,梅其炳,张蓉,顾建文,章翔,高大宽.唐古特大黄多糖对大鼠实验性颅脑外伤的保护作用[J].中国中药杂志,2003,28(10):974-976. |
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| 作者姓名： | 王志鹏 刘莉 梅其炳 张蓉 顾建文 章翔 高大宽 |
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| 作者单位： | 1. 第四军医大学,基础部,药理学教研室,陕西,西安,710032
2. 第四军医大学,西京医院神经外科,陕西,西安,710032 |
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| 基金项目： | 国家自然科学基金资助项目 (3 0 0 0 0 2 2 4) |
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| 摘 要： | 目的 :研究唐古特大黄多糖 (Rheum tanguticum Polysaccharides ,RTP)对大鼠实验性脑外伤的保护作用。方法 :从青海产唐古特大黄中分离提取大黄多糖。SD大鼠 120只分为正常对照组 (6,24 ,48h)、模型组 (6 ,24 ,48h)和多糖 (100 ,200 ,400mg·kg-1)治疗组 (6 ,24 ,48h)共 15组 ,每天灌胃给药 1次 ,5d后 ,复制颅脑坠击伤模型 ,分别在造模后 6 ,24 ,48h测定脑含水量和脑组织超氧化物歧化酶 (SOD) ,Na+ K+ ATP酶活性 ,以及丙二醛(MDA)水平。结果 :RTP可降低脑损伤后的脑含水量和脑组织丙二醛水平 ,升高脑组织SOD和Na+-K+ ATP酶活性 ,作用持续至 48h。结论 :大黄多糖是中药大黄治疗脑损伤的有效成分之一 ,具有神经保护作用。
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| 关 键 词： | 大黄多糖 脑外伤 超氧化物歧化酶 丙二醛 Na+-K+ATP酶 |
| 文章编号： | 1001-5302(2003)10-0974-04 |
| 收稿时间： | 9/5/2002 12:00:00 AM |
Protective Effect of Rheum tanguticum Polysaccharides(RTP) on Traumatic Brain Injury in Rats |
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| WANG Zhi-peng ;LIU Li ;MEI Qi-bing ;ZHANG Rong;GU Jian-wen ;ZHANG Xiang ;GAO Da-kuan.Protective Effect of Rheum tanguticum Polysaccharides(RTP) on Traumatic Brain Injury in Rats[J].China Journal of Chinese Materia Medica,2003,28(10):974-976. |
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| Authors: | WANG Zhi-peng ;LIU Li ;MEI Qi-bing ;ZHANG Rong;GU Jian-wen ;ZHANG Xiang ;GAO Da-kuan |
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| Institution: | Department of Pharmacology, the Fourth Military Medical University, Xian Shaanxi 710032, China. |
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| Abstract: | Objective:To evaluate protective effects of Rheum tanguticum Polysaccharides(RTP) on traumatic brain injury(TBI) in rats. Method: The polysaccharides(RTP) were extracted from Tanguficum Maxim. 120 rats were divided into 15 groups, with 8 rats in each group. RTP at 100,200 and 400 mg·kg-1 were administrated orally once a day for five days,and model of brain injury was made by dropping weight method. Result: RTP reduced water content and malondialdehyde(MDA) levels, and increased total SOD activity and Na +-K + ATPase activity after injuried. Conclusion:The polysaccharides may be one of the effective comptents in Rheum tanguticum , showing significant neuroprotective effects. |
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| Keywords: | Rheum tanguticum polysaccharide traumatic brain injury Na+-K+ ATPase malondialdehyde(MDA) superoxide dismutase(SOD) |
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