| OGFR mRNA在乳腺浸润性导管癌中的表达 |
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| 引用本文： | 胡建功,邢恩鸿,李秀英,王宁.OGFR mRNA在乳腺浸润性导管癌中的表达[J].肿瘤防治研究,2010,37(11):1258-1260. |
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| 作者姓名： | 胡建功 邢恩鸿 李秀英 王宁 |
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| 作者单位： | 1. 承德医学院附属医院病理科,河北承德,067000
2. 承德医学院附属医院中心实验室,河北承德,067000 |
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| 基金项目： | 河北省科学技术研究与发展计划资助项目 |
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| 摘 要： | 目的 探讨乳腺浸润性导管癌中OGFR mRNA的表达意义。方法 采用逆转录-聚合酶链反应（RT-PCR）方法检测乳腺良性上皮增生、浸润性导管癌中OGFR mRNA的表达。结果OGFR mRNA表达量在乳腺良性上皮增生组明显高于浸润性导管癌组（P<0.05）；在浸润性导管癌中的表达与患者年龄、肿瘤体积、组织学分级、雌孕激素受体表达、c-erbB-2表达及淋巴结转移无关（P>0.05）。结论 OGFR mRNA表达减少可以作为乳腺浸润性导管癌的标志；OGFR在mRNA水平表达量减少，可能与乳腺癌的发生发展有关。
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| 关 键 词： | 乳腺 浸润性导管癌 OGFRmRNA RT-PCR |
| 收稿时间： | 2009-9-25 |
| 修稿时间： | 2010-3-2 |
Expression of OGFR mRNA in Invasive Ductal Carcinoma of Breast |
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| HU Jian-gong,XING En-hong,LI Xiu-ying,WANG-ning.Expression of OGFR mRNA in Invasive Ductal Carcinoma of Breast[J].Cancer Research on Prevention and Treatment,2010,37(11):1258-1260. |
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| Authors: | HU Jian-gong XING En-hong LI Xiu-ying WANG-ning |
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| Institution: | 1.Department of Pathology，Affiliated Hospital of Chengde Mediecal College，Chengde 067000，China，2.Research Center |
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| Abstract: | Objective To elucidate the features of OGFR mRNA expression in invasive ductal carcinoma of breast.Methods RT- PCR was used to detect the expression of OGFR mRNA in benign epithelial proliferation and invasive ductal carcinoma tissues of breast.Results The expressing quantity of OGFR mRNA was significantly higher in benign epithelial proliferation than that in invasive ductal carcinoma tissues(P<0.01).There was no significant difference between the expression of OGFR mRNA and patients ages，volumes and grades of tumor，the expression of ER，PR，C-erbB- 2 and lymphatic metastasis(P>0.05).Conclusion The reduced level of OGFR mRNA may serve as a marker of breast invasive ductal carcinoma.The subnormal levels of OGFR mRNA may contribute to the progression of breast carcinoma. |
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| Keywords: | Breast Invasive Ductal Carcinoma OGFRmRNA RT-PCR |
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