| 重复经颅磁刺激对大鼠海马、齿状回胶质纤维酸性蛋白、Ⅲ型补体受体表达的影响 |
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| 引用本文： | 魏莉,林宏,李柱一,刘煜.重复经颅磁刺激对大鼠海马、齿状回胶质纤维酸性蛋白、Ⅲ型补体受体表达的影响[J].临床神经病学杂志,2005,18(3):199-200. |
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| 作者姓名： | 魏莉 林宏 李柱一 刘煜 |
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| 作者单位： | 710038,西安,第四军医大学唐都医院神经内科;710038,西安,第四军医大学唐都医院神经内科;710038,西安,第四军医大学唐都医院神经内科;710038,西安,第四军医大学唐都医院神经内科 |
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| 摘 要： | 目的观察重复经颅磁刺激(rTMS)对大鼠海屿、齿状间星形胶质细胞和小胶质细胞标记物胶质纤维酸性蛋白(GFAP)、Ⅲ型补体受体(OX-42)表达的影响。方法每日1次给予大鼠1Hz、100mT的TMS 10 min，共14d，观察大鼠行为的变化；14d后采用免疫组化ABC法检测其海马、齿状间GFAP、OX-42的表达，并与对照组比较。结果rTMS组、对照组大鼠海马、齿状MGFAP、OX-42阳性表达物在形态、数量等方面差异无显著性。结论本实验条件下的rTMS不会造成大鼠中枢神经系统明显损伤。
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| 关 键 词： | 重复经颅磁刺激 胶质纤维酸性蛋白 Ⅲ型补体受体 |
| 文章编号： | 1004-1648(2005)03-0199-02 |
| 修稿时间： | 2004年7月27日 |
Effects of repetitive transcranial magnetic stimulation on GFAP and OX-42 expression in hippocampus and dentate gyrus in rats |
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| Abstract: | Objective To observe the effects of repetitive transcranial magnetic stimulation (rTMS) on the expression of glial fibrillary acidic protein (GFAP) and OX-42 in hippocampus and dentate gyrus in rats.Methods The rats were treated with 1 Hz, 100 mT TMS 10 min once a day for 14 days, and then the expression of GFAP and OX-42 in hippocampus and dentate gyrus were investigated by ABC technique of immunohistochemistry.Results Compared with the control group, there were no significant difference in the expression of GFAP and OX-42 between the two groups.Conclusion rTMS using our parameters does not cause brain injury in rats. |
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| Keywords: | repetitive transcranial magnetic stimulation GFAP OX-42 |
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