| 人体乳腺癌及卵巢癌组织中C—erb B2基因的扩增 |
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| 引用本文： | 许凯黎 张国玲. 人体乳腺癌及卵巢癌组织中C—erb B2基因的扩增[J]. 上海医学, 1992, 15(8): 461-463 |
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| 作者姓名： | 许凯黎 张国玲 |
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| 作者单位： | 上海市肿瘤研究所，上海市肿瘤研究所，上海市肿瘤研究所，上海医科大学附属肿瘤医院，上海医科大学附属肿瘤医院，上海医科大学附属肿瘤医院 |
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| 摘 要： | 应用C-erb B2探针分析14例乳腺癌,15例卵巢癌组织及相应正常对照组织,结果发现29％乳腺癌及40％卵巢癌组织中出现基因扩增,作者认为检测C-erb B2基因扩增有可能作为上述两种癌组织的潜在性基因诊断的标志物。
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| 关 键 词： | 基因扩增 乳腺癌 卵巢肿瘤 |
AMPLIFICATION OF C-erb B2 IN HUMAN BREAST CANCER AND OVARIAN CANCER TISSUES |
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| Xu Kai-li,et al.. AMPLIFICATION OF C-erb B2 IN HUMAN BREAST CANCER AND OVARIAN CANCER TISSUES[J]. Shanghai Medical Journal, 1992, 15(8): 461-463 |
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| Authors: | Xu Kai-li et al. |
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| Affiliation: | Xu Kai-li,et al. Shanghai Cancer Institute,etc.,Shanghai 200032 |
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| Abstract: | Using a human specific probe to C-erb B2, there are three bands, 8.1Kb, 6.6Kb and 4.7Kb appearing in various human tissue DNA samples digested with EcoR1. Amplication of C-erb B2 was found in 4 of 14 cases with primary breast cancer and 6 of 15 cases with ovarian cancer. On the contrary, there was no amplification occurred in normal tissues. This showed that the amplication of C-erb B2 is one of the tumor markers of breast cancer and ovarian cancer. |
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| Keywords: | Amplification of gene breast cancer ovarian cancer |
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