Susceptibility to endometrial cancer: influence of allelism at p53, glutathione S-transferase (GSTM1 and GSTT1) and cytochrome P-450 (CYP1A1) loci. |
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| Authors: | M Esteller A Garc?-a J M Mart?-nez-Palones J Xercavins J Revent?s |
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| Institution: | Unitat de Recerca Biomedica, Centre d''Investigacions en Bioquimica i Biologia Molecular, Hospital Universitari Materno-Infantil Vall d''Hebron, Barcelona, Spain. |
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| Abstract: | A case-control study was designed to identify associations between polymorphisms at p53, cytochrome P-450 (CYP1A1) and glutathione-S-transferases and endometrial cancer susceptibility. Among all polymorphisms analysed, an insertional variant in p53 (P53PIN3) and two polymorphisms in the 3''-end and exon 7 of CYP1A1 showed significant association with enhanced endometrial cancer risk. |
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